4p1z
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4p1z]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P1Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P1Z FirstGlance]. <br> | <table><tr><td colspan='2'>[[4p1z]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4P1Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4P1Z FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p1z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p1z RCSB], [http://www.ebi.ac.uk/pdbsum/4p1z PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4p1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4p1z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4p1z RCSB], [http://www.ebi.ac.uk/pdbsum/4p1z PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PIWL1_MOUSE PIWL1_MOUSE]] Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Directly binds methylated piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation. Probable component of some RISC complex, which mediates RNA cleavage and translational silencing. Also plays a role in the formation of chromatoid bodies and is required for some miRNAs stability.<ref>PMID:11578866</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 17: | Line 19: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Cora, E | + | [[Category: Cora, E]] |
| - | [[Category: McCarthy, A A | + | [[Category: McCarthy, A A]] |
| - | [[Category: Pillai, R S | + | [[Category: Pillai, R S]] |
[[Category: Mid domain]] | [[Category: Mid domain]] | ||
[[Category: Miwi]] | [[Category: Miwi]] | ||
[[Category: Pirna biogenesis]] | [[Category: Pirna biogenesis]] | ||
[[Category: Rna binding protein]] | [[Category: Rna binding protein]] | ||
Revision as of 11:08, 25 December 2014
Structure of the MID domain from MIWI
| |||||||||||
