2kuo
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kuo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kuo RCSB], [http://www.ebi.ac.uk/pdbsum/2kuo PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2kuo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kuo OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2kuo RCSB], [http://www.ebi.ac.uk/pdbsum/2kuo PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/APLF_HUMAN APLF_HUMAN]] Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.<ref>PMID:17396150</ref> <ref>PMID:17353262</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Cheung, M | + | [[Category: Cheung, M]] |
| - | [[Category: Fenton, A | + | [[Category: Fenton, A]] |
| - | [[Category: Ikura, M | + | [[Category: Ikura, M]] |
| - | [[Category: Koch, C A | + | [[Category: Koch, C A]] |
| - | [[Category: Li, G Y | + | [[Category: Li, G Y]] |
| - | [[Category: McCulloch, R D | + | [[Category: McCulloch, R D]] |
| - | [[Category: Meng, L | + | [[Category: Meng, L]] |
[[Category: Adp-ribose]] | [[Category: Adp-ribose]] | ||
[[Category: Adp-ribosylation]] | [[Category: Adp-ribosylation]] | ||
Revision as of 11:09, 25 December 2014
Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response
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