2me2
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2me2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ME2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ME2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2me2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/9hiv1 9hiv1]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ME2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ME2 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2pv6|2pv6]], [[2me1|2me1]], [[2me3|2me3]], [[2me4|2me4]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2pv6|2pv6]], [[2me1|2me1]], [[2me3|2me3]], [[2me4|2me4]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">env ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">env ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11676 9HIV1])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2me2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2me2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2me2 RCSB], [http://www.ebi.ac.uk/pdbsum/2me2 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2me2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2me2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2me2 RCSB], [http://www.ebi.ac.uk/pdbsum/2me2 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q7SQ48_9HIV1 Q7SQ48_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Disruption of Helix-Capping Residues 671 and 674 Reveals a Role in HIV-1 Entry for a Specialized Hinge Segment of the Membrane Proximal External Region of gp41.,Sun ZY, Cheng Y, Kim M, Song L, Choi J, Kudahl UJ, Brusic V, Chowdhury B, Yu L, Seaman MS, Bellot G, Shih WM, Wagner G, Reinherz EL J Mol Biol. 2013 Sep 26. pii: S0022-2836(13)00614-1. doi:, 10.1016/j.jmb.2013.09.030. PMID:24075869<ref>PMID:24075869</ref> | Disruption of Helix-Capping Residues 671 and 674 Reveals a Role in HIV-1 Entry for a Specialized Hinge Segment of the Membrane Proximal External Region of gp41.,Sun ZY, Cheng Y, Kim M, Song L, Choi J, Kudahl UJ, Brusic V, Chowdhury B, Yu L, Seaman MS, Bellot G, Shih WM, Wagner G, Reinherz EL J Mol Biol. 2013 Sep 26. pii: S0022-2836(13)00614-1. doi:, 10.1016/j.jmb.2013.09.030. PMID:24075869<ref>PMID:24075869</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | + | [[Category: Bellot, G]] | |
| - | [[Category: Bellot, G | + | [[Category: Cheng, Y]] |
| - | [[Category: Cheng, Y | + | [[Category: Choi, J]] |
| - | [[Category: Choi, J | + | [[Category: Chowdhury, B]] |
| - | [[Category: Chowdhury, B | + | [[Category: Kim, M]] |
| - | [[Category: Kim, M | + | [[Category: Reinherz, E L]] |
| - | [[Category: Reinherz, E L | + | [[Category: Shih, W]] |
| - | [[Category: Shih, W | + | [[Category: Song, L]] |
| - | [[Category: Song, L | + | [[Category: Sun, Z J]] |
| - | [[Category: Sun, Z J | + | [[Category: Wagner, G]] |
| - | [[Category: Wagner, G | + | |
[[Category: Helix-hinge-helix]] | [[Category: Helix-hinge-helix]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
[[Category: Mper]] | [[Category: Mper]] | ||
[[Category: Viral fusion]] | [[Category: Viral fusion]] | ||
Revision as of 11:10, 25 December 2014
HIV-1 gp41 clade C Membrane Proximal External Region peptide in DPC micelle
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Categories: Bellot, G | Cheng, Y | Choi, J | Chowdhury, B | Kim, M | Reinherz, E L | Shih, W | Song, L | Sun, Z J | Wagner, G | Helix-hinge-helix | Membrane protein | Mper | Viral fusion
