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1of1
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1of1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type 1 / strain 17)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OF1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OF1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1of1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Herpes_simplex_virus_(type_1_/_strain_17) Herpes simplex virus (type 1 / strain 17)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OF1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1OF1 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCT:(SOUTH)-METHANOCARBA-THYMIDINE'>SCT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SCT:(SOUTH)-METHANOCARBA-THYMIDINE'>SCT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e2h|1e2h]], [[1e2i|1e2i]], [[1e2j|1e2j]], [[1e2k|1e2k]], [[1e2l|1e2l]], [[1e2m|1e2m]], [[1e2n|1e2n]], [[1e2p|1e2p]], [[1ki2|1ki2]], [[1ki3|1ki3]], [[1ki4|1ki4]], [[1ki6|1ki6]], [[1ki7|1ki7]], [[1ki8|1ki8]], [[1qhi|1qhi]], [[1vtk|1vtk]], [[2ki5|2ki5]], [[3vtk|3vtk]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1e2h|1e2h]], [[1e2i|1e2i]], [[1e2j|1e2j]], [[1e2k|1e2k]], [[1e2l|1e2l]], [[1e2m|1e2m]], [[1e2n|1e2n]], [[1e2p|1e2p]], [[1ki2|1ki2]], [[1ki3|1ki3]], [[1ki4|1ki4]], [[1ki6|1ki6]], [[1ki7|1ki7]], [[1ki8|1ki8]], [[1qhi|1qhi]], [[1vtk|1vtk]], [[2ki5|2ki5]], [[3vtk|3vtk]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1of1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1of1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1of1 RCSB], [http://www.ebi.ac.uk/pdbsum/1of1 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1of1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1of1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1of1 RCSB], [http://www.ebi.ac.uk/pdbsum/1of1 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Thymidine kinase]] | [[Category: Thymidine kinase]] | ||
| - | [[Category: Claus, M T | + | [[Category: Claus, M T]] |
| - | [[Category: Folkers, G | + | [[Category: Folkers, G]] |
| - | [[Category: Marquez, V E | + | [[Category: Marquez, V E]] |
| - | [[Category: Scapozza, L | + | [[Category: Scapozza, L]] |
| - | [[Category: Schelling, P | + | [[Category: Schelling, P]] |
| - | [[Category: Schulz, G E | + | [[Category: Schulz, G E]] |
[[Category: Antiviral drug]] | [[Category: Antiviral drug]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
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[[Category: Enzyme-prodrug gene]] | [[Category: Enzyme-prodrug gene]] | ||
[[Category: Kinase]] | [[Category: Kinase]] | ||
| - | [[Category: Thymidine kinase]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 11:11, 25 December 2014
KINETICS AND CRYSTAL STRUCTURE OF THE HERPES SIMPLEX VIRUS TYPE 1 THYMIDINE KINASE INTERACTING WITH (SOUTH)-METHANOCARBA-THYMIDINE
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