2awg
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2awg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AWG FirstGlance]. <br> | <table><tr><td colspan='2'>[[2awg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AWG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2AWG FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FKBP8, FKBP38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FKBP8, FKBP38 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2awg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2awg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2awg RCSB], [http://www.ebi.ac.uk/pdbsum/2awg PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2awg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2awg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2awg RCSB], [http://www.ebi.ac.uk/pdbsum/2awg PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FKBP8_HUMAN FKBP8_HUMAN]] Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.<ref>PMID:12510191</ref> <ref>PMID:16176796</ref> <ref>PMID:15757646</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 19: | Line 21: | ||
==See Also== | ==See Also== | ||
*[[FK506 binding protein|FK506 binding protein]] | *[[FK506 binding protein|FK506 binding protein]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith, C | + | [[Category: Arrowsmith, C]] |
| - | [[Category: Bochkarev, A | + | [[Category: Bochkarev, A]] |
| - | [[Category: Davis, T | + | [[Category: Davis, T]] |
| - | [[Category: Dhe-Paganon, S | + | [[Category: Dhe-Paganon, S]] |
| - | [[Category: Edwards, A | + | [[Category: Edwards, A]] |
| - | [[Category: Finerty, P | + | [[Category: Finerty, P]] |
| - | [[Category: Mackenzie, F | + | [[Category: Mackenzie, F]] |
| - | [[Category: Newman, E M | + | [[Category: Newman, E M]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Sundstrom, M | + | [[Category: Sundstrom, M]] |
| - | [[Category: Walker, J R | + | [[Category: Walker, J R]] |
| - | [[Category: Weigelt, J | + | [[Category: Weigelt, J]] |
[[Category: Bcl-2 inhibitor]] | [[Category: Bcl-2 inhibitor]] | ||
[[Category: Fkbp-type]] | [[Category: Fkbp-type]] | ||
| Line 40: | Line 44: | ||
[[Category: Shh signalling antagonist]] | [[Category: Shh signalling antagonist]] | ||
[[Category: Signaling protein inhibitor]] | [[Category: Signaling protein inhibitor]] | ||
| - | [[Category: Structural genomics consortium]] | ||
Revision as of 11:13, 25 December 2014
Structure of the PPIase domain of the Human FK506-binding protein 8
| |||||||||||
Categories: Homo sapiens | Arrowsmith, C | Bochkarev, A | Davis, T | Dhe-Paganon, S | Edwards, A | Finerty, P | Mackenzie, F | Newman, E M | Structural genomic | Sundstrom, M | Walker, J R | Weigelt, J | Bcl-2 inhibitor | Fkbp-type | Ppiase | Sgc | Shh signalling antagonist | Signaling protein inhibitor
