1kkq

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1kkq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KKQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[1kkq]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KKQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KKQ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=471:N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)+PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE'>471</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=471:N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL)+PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE'>471</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k7l|1k7l]], [[1k74|1k74]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k7l|1k7l]], [[1k74|1k74]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">human ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">human ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kkq RCSB], [http://www.ebi.ac.uk/pdbsum/1kkq PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kkq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kkq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kkq RCSB], [http://www.ebi.ac.uk/pdbsum/1kkq PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Cobb, J E.]]
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[[Category: Cobb, J E]]
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[[Category: Galardi, C M.]]
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[[Category: Galardi, C M]]
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[[Category: Lambert, M H.]]
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[[Category: Lambert, M H]]
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[[Category: McKee, D D.]]
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[[Category: McKee, D D]]
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[[Category: Montana, V G.]]
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[[Category: Montana, V G]]
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[[Category: Nolte, R T.]]
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[[Category: Nolte, R T]]
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[[Category: Parks, D J.]]
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[[Category: Parks, D J]]
[[Category: Shearer, B G]]
[[Category: Shearer, B G]]
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[[Category: Stanley, T B.]]
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[[Category: Stanley, T B]]
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[[Category: Xu, H E.]]
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[[Category: Xu, H E]]
[[Category: Nuclear corepressor nuclear hormone receptors antagonist]]
[[Category: Nuclear corepressor nuclear hormone receptors antagonist]]
[[Category: Transcription]]
[[Category: Transcription]]

Revision as of 11:14, 25 December 2014

Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif

1kkq, resolution 3.00Å

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