3nqu
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nqu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nqu RCSB], [http://www.ebi.ac.uk/pdbsum/3nqu PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nqu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nqu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nqu RCSB], [http://www.ebi.ac.uk/pdbsum/3nqu PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CENPA_HUMAN CENPA_HUMAN]] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).<ref>PMID:20739937</ref> <ref>PMID:21478274</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Revision as of 11:16, 25 December 2014
Crystal structure of partially trypsinized (CENP-A/H4)2 heterotetramer
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