2d2a
From Proteopedia
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| - | [[Image:2d2a.gif|left|200px]] | + | [[Image:2d2a.gif|left|200px]] |
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| - | '''Crystal Structure of Escherichia coli SufA Involved in Biosynthesis of Iron-sulfur Clusters''' | + | {{Structure |
| + | |PDB= 2d2a |SIZE=350|CAPTION= <scene name='initialview01'>2d2a</scene>, resolution 2.70Å | ||
| + | |SITE= | ||
| + | |LIGAND= | ||
| + | |ACTIVITY= | ||
| + | |GENE= | ||
| + | }} | ||
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| + | '''Crystal Structure of Escherichia coli SufA Involved in Biosynthesis of Iron-sulfur Clusters''' | ||
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==Overview== | ==Overview== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2D2A is a [ | + | 2D2A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D2A OCA]. |
==Reference== | ==Reference== | ||
| - | Crystal structure of Escherichia coli SufA involved in biosynthesis of iron-sulfur clusters: implications for a functional dimer., Wada K, Hasegawa Y, Gong Z, Minami Y, Fukuyama K, Takahashi Y, FEBS Lett. 2005 Dec 5;579(29):6543-8. Epub 2005 Nov 15. PMID:[http:// | + | Crystal structure of Escherichia coli SufA involved in biosynthesis of iron-sulfur clusters: implications for a functional dimer., Wada K, Hasegawa Y, Gong Z, Minami Y, Fukuyama K, Takahashi Y, FEBS Lett. 2005 Dec 5;579(29):6543-8. Epub 2005 Nov 15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16298366 16298366] |
[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: yadr]] | [[Category: yadr]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:22:27 2008'' |
Revision as of 14:22, 20 March 2008
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| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal Structure of Escherichia coli SufA Involved in Biosynthesis of Iron-sulfur Clusters
Overview
IscA and SufA are paralogous proteins that play crucial roles in the biosynthesis of Fe-S clusters, perhaps through a mechanism involving transient Fe-S cluster formation. We have determined the crystal structure of E. coli SufA at 2.7A resolution. SufA exists as a homodimer, in contrast to the tetrameric organization of IscA. Furthermore, a C-terminal segment containing two essential cysteine residues (Cys-Gly-Cys), which is disordered in the IscA structure, is clearly visible in one molecule (the alpha1 subunit) of the SufA homodimer. Although this segment is disordered in the other molecule (the alpha2 subunit), computer modeling of this segment based on the well-defined conformation of alpha1 subunit suggests that the four cysteine residues (Cys114 and Cys116 in each subunit) in the Cys-Gly-Cys motif are positioned in close proximity at the dimer interface. The arrangement of these cysteines together with the nearby Glu118 in SufA dimer may allow coordination of an Fe-S cluster and/or an Fe atom.
About this Structure
2D2A is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Crystal structure of Escherichia coli SufA involved in biosynthesis of iron-sulfur clusters: implications for a functional dimer., Wada K, Hasegawa Y, Gong Z, Minami Y, Fukuyama K, Takahashi Y, FEBS Lett. 2005 Dec 5;579(29):6543-8. Epub 2005 Nov 15. PMID:16298366
Page seeded by OCA on Thu Mar 20 16:22:27 2008
Categories: Escherichia coli | Single protein | Fukuyama, K. | Gong, Z. | Hasegawa, Y. | Minami, Y. | Takahashi, Y. | Wada, K. | Iron | Iron-sulfur cluster | Isca | Suf | Sufa | Yadr
