3q5u
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3q5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q5U FirstGlance]. <br> | <table><tr><td colspan='2'>[[3q5u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q5U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3Q5U FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1y2a|1y2a]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1y2a|1y2a]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kpna2, Rch1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Kpna2, Rch1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q5u RCSB], [http://www.ebi.ac.uk/pdbsum/3q5u PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3q5u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q5u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3q5u RCSB], [http://www.ebi.ac.uk/pdbsum/3q5u PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IMA2_MOUSE IMA2_MOUSE]] Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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A minimal NLS in human phospholipid scramblase 4 that binds only the minor NLS-binding site of importin {alpha}1.,Lott K, Bhardwaj A, Sims PJ, Cingolani G J Biol Chem. 2011 Jun 20. PMID:21690087<ref>PMID:21690087</ref> | A minimal NLS in human phospholipid scramblase 4 that binds only the minor NLS-binding site of importin {alpha}1.,Lott K, Bhardwaj A, Sims PJ, Cingolani G J Biol Chem. 2011 Jun 20. PMID:21690087<ref>PMID:21690087</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Importin|Importin]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Bhardwaj, A | + | [[Category: Bhardwaj, A]] |
| - | [[Category: Cingolani, G | + | [[Category: Cingolani, G]] |
[[Category: Armadillo repeat]] | [[Category: Armadillo repeat]] | ||
[[Category: Protein transport]] | [[Category: Protein transport]] | ||
[[Category: Protein transport-membrane protein complex]] | [[Category: Protein transport-membrane protein complex]] | ||
Revision as of 11:21, 25 December 2014
A minimal NLS from human scramblase 4 complexed with importin alpha
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