4o9r

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4o9r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O9R FirstGlance]. <br>
<table><tr><td colspan='2'>[[4o9r]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O9R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O9R FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CY8:CYCLOPAMINE'>CY8</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CY8:CYCLOPAMINE'>CY8</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o9r RCSB], [http://www.ebi.ac.uk/pdbsum/4o9r PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o9r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o9r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4o9r RCSB], [http://www.ebi.ac.uk/pdbsum/4o9r PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/SMO_HUMAN SMO_HUMAN]] G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia.<ref>PMID:19592253</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography.,Weierstall U, James D, Wang C, White TA, Wang D, Liu W, Spence JC, Bruce Doak R, Nelson G, Fromme P, Fromme R, Grotjohann I, Kupitz C, Zatsepin NA, Liu H, Basu S, Wacker D, Han GW, Katritch V, Boutet S, Messerschmidt M, Williams GJ, Koglin JE, Marvin Seibert M, Klinker M, Gati C, Shoeman RL, Barty A, Chapman HN, Kirian RA, Beyerlein KR, Stevens RC, Li D, Shah ST, Howe N, Caffrey M, Cherezov V Nat Commun. 2014;5:3309. doi: 10.1038/ncomms4309. PMID:24525480<ref>PMID:24525480</ref>
Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography.,Weierstall U, James D, Wang C, White TA, Wang D, Liu W, Spence JC, Bruce Doak R, Nelson G, Fromme P, Fromme R, Grotjohann I, Kupitz C, Zatsepin NA, Liu H, Basu S, Wacker D, Han GW, Katritch V, Boutet S, Messerschmidt M, Williams GJ, Koglin JE, Marvin Seibert M, Klinker M, Gati C, Shoeman RL, Barty A, Chapman HN, Kirian RA, Beyerlein KR, Stevens RC, Li D, Shah ST, Howe N, Caffrey M, Cherezov V Nat Commun. 2014;5:3309. doi: 10.1038/ncomms4309. PMID:24525480<ref>PMID:24525480</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
== References ==
== References ==
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</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Bacillus coli migula 1895]]
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[[Category: Barty, A.]]
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[[Category: Barty, A]]
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[[Category: Basu, S.]]
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[[Category: Basu, S]]
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[[Category: Beyerlein, K R.]]
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[[Category: Beyerlein, K R]]
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[[Category: Boutet, S.]]
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[[Category: Boutet, S]]
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[[Category: Caffrey, M.]]
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[[Category: Caffrey, M]]
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[[Category: Chapman, H N.]]
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[[Category: Chapman, H N]]
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[[Category: Cherezov, V.]]
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[[Category: Cherezov, V]]
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[[Category: Doak, R B.]]
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[[Category: Doak, R B]]
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[[Category: Fromme, P.]]
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[[Category: Fromme, P]]
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[[Category: Fromme, R.]]
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[[Category: Fromme, R]]
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[[Category: GPCR, GPCR Network.]]
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[[Category: GPCR, GPCR Network]]
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[[Category: Gati, C.]]
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[[Category: Gati, C]]
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[[Category: Grotjohann, I.]]
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[[Category: Grotjohann, I]]
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[[Category: Han, G W.]]
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[[Category: Han, G W]]
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[[Category: Howe, N.]]
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[[Category: Howe, N]]
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[[Category: James, D.]]
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[[Category: James, D]]
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[[Category: Katritch, V.]]
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[[Category: Katritch, V]]
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[[Category: Kirian, R A.]]
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[[Category: Kirian, R A]]
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[[Category: Klinker, M.]]
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[[Category: Klinker, M]]
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[[Category: Koglin, J E.]]
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[[Category: Koglin, J E]]
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[[Category: Kupitz, C.]]
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[[Category: Kupitz, C]]
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[[Category: Li, D.]]
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[[Category: Li, D]]
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[[Category: Liu, H.]]
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[[Category: Liu, H]]
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[[Category: Liu, W.]]
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[[Category: Liu, W]]
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[[Category: Messerschmidt, M.]]
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[[Category: Messerschmidt, M]]
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[[Category: Nelson, G.]]
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[[Category: Nelson, G]]
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[[Category: Seibert, M M.]]
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[[Category: Seibert, M M]]
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[[Category: Shah, S T.A.]]
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[[Category: Shah, S T.A]]
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[[Category: Shoeman, R L.]]
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[[Category: Shoeman, R L]]
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[[Category: Spence, J C.H.]]
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[[Category: Spence, J C.H]]
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[[Category: Stevens, R C.]]
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[[Category: Stevens, R C]]
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[[Category: Wacker, D.]]
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[[Category: Wacker, D]]
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[[Category: Wang, C.]]
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[[Category: Wang, C]]
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[[Category: Wang, D.]]
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[[Category: Wang, D]]
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[[Category: Weierstall, U.]]
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[[Category: Weierstall, U]]
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[[Category: White, T A.]]
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[[Category: White, T A]]
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[[Category: Willams, G J.]]
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[[Category: Willams, G J]]
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[[Category: Zatsepin, N A.]]
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[[Category: Zatsepin, N A]]
[[Category: Cyclopamine]]
[[Category: Cyclopamine]]
[[Category: Free electron laser]]
[[Category: Free electron laser]]

Revision as of 11:25, 25 December 2014

Human Smoothened Receptor structure in complex with cyclopamine

4o9r, resolution 3.20Å

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