This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2ovu
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ovu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OVU FirstGlance]. <br> | <table><tr><td colspan='2'>[[2ovu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Canavalia_gladiata Canavalia gladiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OVU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2OVU FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=MMA:O1-METHYL-MANNOSE'>MMA</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ow4|2ow4]], [[2p2k|2p2k]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2ow4|2ow4]], [[2p2k|2p2k]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ovu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ovu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ovu RCSB], [http://www.ebi.ac.uk/pdbsum/2ovu PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ovu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ovu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ovu RCSB], [http://www.ebi.ac.uk/pdbsum/2ovu PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CONA_CANGL CONA_CANGL]] Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.<ref>PMID:15935326</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 33: | Line 35: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Canavalia gladiata]] | [[Category: Canavalia gladiata]] | ||
| - | [[Category: Azevedo, W F.de | + | [[Category: Azevedo, W F.de]] |
| - | [[Category: Benevides, R G | + | [[Category: Benevides, R G]] |
| - | [[Category: Bezerra, G A | + | [[Category: Bezerra, G A]] |
| - | [[Category: Cavada, B S | + | [[Category: Cavada, B S]] |
| - | [[Category: Delatorre, P | + | [[Category: Delatorre, P]] |
| - | [[Category: Moreno, F B.M B | + | [[Category: Moreno, F B.M B]] |
| - | [[Category: Oliveira, T M.de | + | [[Category: Oliveira, T M.de]] |
| - | [[Category: Rocha, B A.M da | + | [[Category: Rocha, B A.M da]] |
| - | [[Category: Souza, E P.de | + | [[Category: Souza, E P.de]] |
| - | + | ||
[[Category: Lectin]] | [[Category: Lectin]] | ||
[[Category: Man1-2mano-me]] | [[Category: Man1-2mano-me]] | ||
[[Category: Sugar binding protein]] | [[Category: Sugar binding protein]] | ||
Revision as of 11:26, 25 December 2014
Crystal strucure of a lectin from Canavalia gladiata (CGL) in complex with man1-2man-OMe
| |||||||||||
