3u0x
From Proteopedia
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<StructureSection load='3u0x' size='340' side='right' caption='[[3u0x]], [[Resolution|resolution]] 1.85Å' scene=''> | <StructureSection load='3u0x' size='340' side='right' caption='[[3u0x]], [[Resolution|resolution]] 1.85Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3u0x]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U0X FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[3u0x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U0X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U0X FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTI:1-(3-PHENYL-1,2,4-THIADIAZOL-5-YL)PIPERAZINE'>GTI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GTI:1-(3-PHENYL-1,2,4-THIADIAZOL-5-YL)PIPERAZINE'>GTI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lz7|1lz7]], [[1lzj|1lzj]], [[2rit|2rit]], [[2rix|2rix]], [[2rj8|2rj8]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lz7|1lz7]], [[1lzj|1lzj]], [[2rit|2rit]], [[2rix|2rix]], [[2rj8|2rj8]]</td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fucosylgalactoside_3-alpha-galactosyltransferase Fucosylgalactoside 3-alpha-galactosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.37 2.4.1.37] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fucosylgalactoside_3-alpha-galactosyltransferase Fucosylgalactoside 3-alpha-galactosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.37 2.4.1.37] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u0x RCSB], [http://www.ebi.ac.uk/pdbsum/3u0x PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u0x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u0x RCSB], [http://www.ebi.ac.uk/pdbsum/3u0x PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]] | [[Category: Fucosylgalactoside 3-alpha-galactosyltransferase]] | ||
| + | [[Category: Human]] | ||
[[Category: Jorgensen, R]] | [[Category: Jorgensen, R]] | ||
[[Category: Palcic, M M]] | [[Category: Palcic, M M]] | ||
Revision as of 11:28, 25 December 2014
Crystal structure of the B-specific-1,3-galactosyltransferase (GTB) in complex with compound 382
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Categories: Fucosylgalactoside 3-alpha-galactosyltransferase | Human | Jorgensen, R | Palcic, M M | Abo | Blood group antigen | Glycoprotein | Glycosyltransferase | H-antigen acceptor | Manganese | Membrane | Metal-binding | Open conformation | Rossmann fold | Transferase gtb | Transferase-transferase inhibitor complex | Udp-gal
