2giz
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2giz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GIZ FirstGlance]. <br> | <table><tr><td colspan='2'>[[2giz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Naja_atra Naja atra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GIZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2GIZ FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2giz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2giz RCSB], [http://www.ebi.ac.uk/pdbsum/2giz PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2giz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2giz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2giz RCSB], [http://www.ebi.ac.uk/pdbsum/2giz PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CRVP1_NAJAT CRVP1_NAJAT]] Inhibits calcium-activated potassium channels (KCa1.1/KCNMA1), voltage-gated potassium channel Kv1.3/KCNA3, and the calcium release channel/ryanodine receptor (RyR). Binds specifically to type 1 RyR (RyR1) from skeletal muscle. Inhibit both the binding of ryanodine to RyR1, and RyR1's calcium-channel activity. Inhibits carbachol-induced muscle contraction and weakly blocks muscle contraction evoked by potassium.<ref>PMID:15581679</ref> <ref>PMID:17070778</ref> <ref>PMID:18658224</ref> <ref>PMID:16042391</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Naja atra]] | [[Category: Naja atra]] | ||
| - | [[Category: Jiang, T | + | [[Category: Jiang, T]] |
| - | [[Category: Li, H | + | [[Category: Li, H]] |
| - | [[Category: Lin, Z | + | [[Category: Lin, Z]] |
| - | [[Category: Qi, Z | + | [[Category: Qi, Z]] |
| - | [[Category: Shu, Y | + | [[Category: Shu, Y]] |
| - | [[Category: Wang, F | + | [[Category: Wang, F]] |
| - | [[Category: Yin, C | + | [[Category: Yin, C]] |
| - | [[Category: Zhou, Y | + | [[Category: Zhou, Y]] |
[[Category: Blocker]] | [[Category: Blocker]] | ||
[[Category: Crisp]] | [[Category: Crisp]] | ||
Revision as of 11:29, 25 December 2014
Structural and functional analysis of Natrin, a member of crisp-3 family blocks a variety of ion channels
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