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3dsl
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3dsl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararaca Bothrops jararaca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DSL FirstGlance]. <br> | <table><tr><td colspan='2'>[[3dsl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bothrops_jararaca Bothrops jararaca]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3DSL FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLE:FUROYL-LEUCINE'>FLE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FLE:FUROYL-LEUCINE'>FLE</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bothropasin Bothropasin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.49 3.4.24.49] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Bothropasin Bothropasin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.49 3.4.24.49] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dsl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dsl RCSB], [http://www.ebi.ac.uk/pdbsum/3dsl PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dsl OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3dsl RCSB], [http://www.ebi.ac.uk/pdbsum/3dsl PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VMBOP_BOTJA VMBOP_BOTJA]] Zinc metalloproteinase-disintegrin-like bothropasin: has caseinolytic activity. Causes hemorrhage on rabbit skin and causes myonecrosis in mouse tibialis anterior muscle.<ref>PMID:12565741</ref> <ref>PMID:6819660</ref> Disintegrin-like bothropasin: inhibits platelet aggregation.<ref>PMID:12565741</ref> <ref>PMID:6819660</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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[[Category: Bothropasin]] | [[Category: Bothropasin]] | ||
[[Category: Bothrops jararaca]] | [[Category: Bothrops jararaca]] | ||
| - | [[Category: Ambrosio, A | + | [[Category: Ambrosio, A]] |
| - | [[Category: Garratt, R C | + | [[Category: Garratt, R C]] |
| - | [[Category: Muniz, J R.C | + | [[Category: Muniz, J R.C]] |
| - | [[Category: Oliva, G | + | [[Category: Oliva, G]] |
| - | [[Category: Selistre-de-Araujo, H S | + | [[Category: Selistre-de-Araujo, H S]] |
| - | [[Category: Souza, D H.F | + | [[Category: Souza, D H.F]] |
[[Category: Blood coagulation]] | [[Category: Blood coagulation]] | ||
[[Category: Cell adhesion]] | [[Category: Cell adhesion]] | ||
Revision as of 11:33, 25 December 2014
The Three-dimensional Structure of Bothropasin, the Main Hemorrhagic Factor from Bothrops jararaca venom.
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Categories: Bothropasin | Bothrops jararaca | Ambrosio, A | Garratt, R C | Muniz, J R.C | Oliva, G | Selistre-de-Araujo, H S | Souza, D H.F | Blood coagulation | Cell adhesion | Disintegrin | Glycoprotein | Hydrolase | Metal-binding | Metalloprotease | Protease | Secreted | Snake venom | Toxin | Zymogen
