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1npi
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1npi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tityus_serrulatus Tityus serrulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NPI FirstGlance]. <br> | <table><tr><td colspan='2'>[[1npi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Tityus_serrulatus Tityus serrulatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NPI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1NPI FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1npi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1npi RCSB], [http://www.ebi.ac.uk/pdbsum/1npi PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1npi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1npi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1npi RCSB], [http://www.ebi.ac.uk/pdbsum/1npi PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SCX7_TITSE SCX7_TITSE]] Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. In addition, it stimulates the release of NO, IL-6 and TNF-alpha in J774.1 cells (PubMed:21549737). This toxin is active against both mammals and insects.<ref>PMID:21549737</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Tityus serrulatus]] | [[Category: Tityus serrulatus]] | ||
| - | [[Category: Marangoni, S | + | [[Category: Marangoni, S]] |
| - | [[Category: Pinheiro, C B | + | [[Category: Pinheiro, C B]] |
| - | [[Category: Polikarpov, I | + | [[Category: Polikarpov, I]] |
| - | [[Category: Toyama, M H | + | [[Category: Toyama, M H]] |
[[Category: Toxin]] | [[Category: Toxin]] | ||
[[Category: Xcitatory neurotoxin]] | [[Category: Xcitatory neurotoxin]] | ||
Revision as of 11:37, 25 December 2014
Tityus Serrulatus Neurotoxin (Ts1) at atomic resolution
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