4gd4
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gd4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gd4 RCSB], [http://www.ebi.ac.uk/pdbsum/4gd4 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gd4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gd4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gd4 RCSB], [http://www.ebi.ac.uk/pdbsum/4gd4 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KDM4A_HUMAN KDM4A_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref> Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref> | ||
==See Also== | ==See Also== | ||
*[[Jumonji domain-containing protein 2A|Jumonji domain-containing protein 2A]] | *[[Jumonji domain-containing protein 2A|Jumonji domain-containing protein 2A]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 11:57, 25 December 2014
Crystal Structure of JMJD2A Complexed with Inhibitor
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Categories: Human | Arrowsmith, C H | Bountra, C | Edwards, A | King, O N.F | Krojer, T | McDonough, M A | Structural genomic | Schofield, C J | 2-oxoglutarate | Alpha-ketoglutarate | Chromatin regulator | Demethylation | Dioxygenase | Iron | Jmjc domain | Nucleus | Oxidoreductase | Oxidoreductase-oxidoreductase inhibitor complex | Sgc | Transcription
