4cwq
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cwq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CWQ FirstGlance]. <br> | <table><tr><td colspan='2'>[[4cwq]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CWQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CWQ FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=W2D:2-AMINO-5-(1,3-BENZODIOXOL-5-YLMETHYL)[1,2,4]TRIAZOLO[1,5-C]QUINAZOLINE-8-SULFONAMIDE'>W2D</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=W2D:2-AMINO-5-(1,3-BENZODIOXOL-5-YLMETHYL)[1,2,4]TRIAZOLO[1,5-C]QUINAZOLINE-8-SULFONAMIDE'>W2D</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cwf|4cwf]], [[4cwn|4cwn]], [[4cwo|4cwo]], [[4cwp|4cwp]], [[4cwr|4cwr]], [[4cws|4cws]], [[4cwt|4cwt]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cwf|4cwf]], [[4cwn|4cwn]], [[4cwo|4cwo]], [[4cwp|4cwp]], [[4cwr|4cwr]], [[4cws|4cws]], [[4cwt|4cwt]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cwq RCSB], [http://www.ebi.ac.uk/pdbsum/4cwq PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cwq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cwq OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cwq RCSB], [http://www.ebi.ac.uk/pdbsum/4cwq PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Amboldi, N | + | [[Category: Amboldi, N]] |
| - | [[Category: Brasca, G | + | [[Category: Brasca, G]] |
| - | [[Category: Caronni, D | + | [[Category: Caronni, D]] |
| - | [[Category: Casale, E | + | [[Category: Casale, E]] |
| - | [[Category: Casuscelli, F | + | [[Category: Casuscelli, F]] |
| - | [[Category: Colombo, N | + | [[Category: Colombo, N]] |
| - | [[Category: Dalvit, C | + | [[Category: Dalvit, C]] |
| - | [[Category: Felder, E R | + | [[Category: Felder, E R]] |
| - | [[Category: Fogliatto, G | + | [[Category: Fogliatto, G]] |
| - | [[Category: Isacchi, A | + | [[Category: Isacchi, A]] |
| - | [[Category: Mantegani, S | + | [[Category: Mantegani, S]] |
| - | [[Category: Polucci, P | + | [[Category: Polucci, P]] |
| - | [[Category: Riceputi, L | + | [[Category: Riceputi, L]] |
| - | [[Category: Sola, F | + | [[Category: Sola, F]] |
| - | [[Category: Visco, C | + | [[Category: Visco, C]] |
| - | [[Category: Zuccotto, F | + | [[Category: Zuccotto, F]] |
[[Category: Chaperone]] | [[Category: Chaperone]] | ||
Revision as of 12:01, 25 December 2014
Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor
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Categories: Amboldi, N | Brasca, G | Caronni, D | Casale, E | Casuscelli, F | Colombo, N | Dalvit, C | Felder, E R | Fogliatto, G | Isacchi, A | Mantegani, S | Polucci, P | Riceputi, L | Sola, F | Visco, C | Zuccotto, F | Chaperone
