3j05
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3j05]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J05 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3j05]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_1 Dengue virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J05 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J05 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j05 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j05 RCSB], [http://www.ebi.ac.uk/pdbsum/3j05 PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j05 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j05 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j05 RCSB], [http://www.ebi.ac.uk/pdbsum/3j05 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/Q689G3_9FLAV Q689G3_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS013754_004_099774] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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The structural basis for serotype-specific neutralization of dengue virus by a human antibody.,Teoh EP, Kukkaro P, Teo EW, Lim AP, Tan TT, Yip A, Schul W, Aung M, Kostyuchenko VA, Leo YS, Chan SH, Smith KG, Chan AH, Zou G, Ooi EE, Kemeny DM, Tan GK, Ng JK, Ng ML, Alonso S, Fisher D, Shi PY, Hanson BJ, Lok SM, Macary PA Sci Transl Med. 2012 Jun 20;4(139):139ra83. PMID:22723463<ref>PMID:22723463</ref> | The structural basis for serotype-specific neutralization of dengue virus by a human antibody.,Teoh EP, Kukkaro P, Teo EW, Lim AP, Tan TT, Yip A, Schul W, Aung M, Kostyuchenko VA, Leo YS, Chan SH, Smith KG, Chan AH, Zou G, Ooi EE, Kemeny DM, Tan GK, Ng JK, Ng ML, Alonso S, Fisher D, Shi PY, Hanson BJ, Lok SM, Macary PA Sci Transl Med. 2012 Jun 20;4(139):139ra83. PMID:22723463<ref>PMID:22723463</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Dengue virus 1]] | [[Category: Dengue virus 1]] | ||
| - | [[Category: Alonso, S | + | [[Category: Alonso, S]] |
| - | [[Category: Chan, S H | + | [[Category: Chan, S H]] |
| - | [[Category: Fisher, D | + | [[Category: Fisher, D]] |
| - | [[Category: Hanson, B | + | [[Category: Hanson, B]] |
| - | [[Category: Kemeny, D M | + | [[Category: Kemeny, D M]] |
| - | [[Category: Kukkaro, P | + | [[Category: Kukkaro, P]] |
| - | [[Category: Leo, Y S | + | [[Category: Leo, Y S]] |
| - | [[Category: Lim, A | + | [[Category: Lim, A]] |
| - | [[Category: Lok, S M | + | [[Category: Lok, S M]] |
| - | [[Category: MacAry, P A | + | [[Category: MacAry, P A]] |
| - | [[Category: Ng, G | + | [[Category: Ng, G]] |
| - | [[Category: Ng, M L | + | [[Category: Ng, M L]] |
| - | [[Category: Ooi, E E | + | [[Category: Ooi, E E]] |
| - | [[Category: Schul, W | + | [[Category: Schul, W]] |
| - | [[Category: Shi, P Y | + | [[Category: Shi, P Y]] |
| - | [[Category: Smith, K G.C | + | [[Category: Smith, K G.C]] |
| - | [[Category: Tan, T T | + | [[Category: Tan, T T]] |
| - | [[Category: Teo, E W | + | [[Category: Teo, E W]] |
| - | [[Category: Teoh, E P | + | [[Category: Teoh, E P]] |
| - | [[Category: Yip, A | + | [[Category: Yip, A]] |
[[Category: Dengue]] | [[Category: Dengue]] | ||
[[Category: E protein]] | [[Category: E protein]] | ||
Revision as of 12:04, 25 December 2014
Three-dimensional structure of Dengue virus serotype 1 complexed with HMAb 14c10 Fab
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Categories: Dengue virus 1 | Alonso, S | Chan, S H | Fisher, D | Hanson, B | Kemeny, D M | Kukkaro, P | Leo, Y S | Lim, A | Lok, S M | MacAry, P A | Ng, G | Ng, M L | Ooi, E E | Schul, W | Shi, P Y | Smith, K G.C | Tan, T T | Teo, E W | Teoh, E P | Yip, A | Dengue | E protein | Envelope protein | Flavivirus | Mature virus | Serotype 1 | Virus
