4cth
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4cth]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CTH FirstGlance]. <br> | <table><tr><td colspan='2'>[[4cth]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CTH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CTH FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RDF:N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN'>RDF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=RDF:N-ALPHA-L-RHAMNOPYRANOSYLOXY(HYDROXYPHOSPHINYL)-L-LEUCYL-L-TRYPTOPHAN'>RDF</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Neprilysin Neprilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.11 3.4.24.11] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Neprilysin Neprilysin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.11 3.4.24.11] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cth RCSB], [http://www.ebi.ac.uk/pdbsum/4cth PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cth OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cth RCSB], [http://www.ebi.ac.uk/pdbsum/4cth PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NEP_HUMAN NEP_HUMAN]] Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers.<ref>PMID:2531377</ref> <ref>PMID:15283675</ref> <ref>PMID:20876573</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Neprilysin]] | [[Category: Neprilysin]] | ||
| - | [[Category: Andersson, C | + | [[Category: Andersson, C]] |
| - | [[Category: Burrell, M | + | [[Category: Burrell, M]] |
| - | [[Category: Digby, S | + | [[Category: Digby, S]] |
| - | [[Category: Fowler, S B | + | [[Category: Fowler, S B]] |
| - | [[Category: Grudzinska, J | + | [[Category: Grudzinska, J]] |
| - | [[Category: Haupts, U | + | [[Category: Haupts, U]] |
| - | [[Category: Jermutus, L | + | [[Category: Jermutus, L]] |
| - | [[Category: Olsson, L | + | [[Category: Olsson, L]] |
| - | [[Category: Sandercock, A | + | [[Category: Sandercock, A]] |
| - | [[Category: Snijder, A | + | [[Category: Snijder, A]] |
| - | [[Category: Tebbe, J | + | [[Category: Tebbe, J]] |
| - | [[Category: Webster, C I | + | [[Category: Webster, C I]] |
[[Category: Alzheimer's disease]] | [[Category: Alzheimer's disease]] | ||
[[Category: Amyloid beta]] | [[Category: Amyloid beta]] | ||
[[Category: Enzyme engineering]] | [[Category: Enzyme engineering]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
Revision as of 12:07, 25 December 2014
Neprilysin variant G399V,G714K in complex with phosphoramidon
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