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2era
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2era]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Laticauda_semifasciata Laticauda semifasciata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERA FirstGlance]. <br> | <table><tr><td colspan='2'>[[2era]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Laticauda_semifasciata Laticauda semifasciata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ERA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ERA FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2era FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2era OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2era RCSB], [http://www.ebi.ac.uk/pdbsum/2era PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2era FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2era OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2era RCSB], [http://www.ebi.ac.uk/pdbsum/2era PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NXSA_LATSE NXSA_LATSE]] Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), and with low affinity to neuronal alpha-7 nAChRs. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Blocks the extracellular increase of dopamine evoked by nicotine at 4.2 uM concentrations.<ref>PMID:9305882</ref> <ref>PMID:9840221</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Laticauda semifasciata]] | [[Category: Laticauda semifasciata]] | ||
| - | [[Category: Arnoux, B | + | [[Category: Arnoux, B]] |
| - | [[Category: Ducruix, A | + | [[Category: Ducruix, A]] |
| - | [[Category: Gaucher, J F | + | [[Category: Gaucher, J F]] |
| - | [[Category: Menez, A | + | [[Category: Menez, A]] |
| - | [[Category: Menez, R | + | [[Category: Menez, R]] |
[[Category: Neurotoxin]] | [[Category: Neurotoxin]] | ||
[[Category: Postsynaptic neurotoxin]] | [[Category: Postsynaptic neurotoxin]] | ||
[[Category: Snake neurotoxin]] | [[Category: Snake neurotoxin]] | ||
[[Category: Venom]] | [[Category: Venom]] | ||
Revision as of 12:10, 25 December 2014
RECOMBINANT ERABUTOXIN A, S8G MUTANT
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