4lv8
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lv8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4lv8 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4lv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4lv8 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4lv8 RCSB], [http://www.ebi.ac.uk/pdbsum/4lv8 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IIGP1_MOUSE IIGP1_MOUSE]] GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.<ref>PMID:11907101</ref> <ref>PMID:16304607</ref> <ref>PMID:19242543</ref> <ref>PMID:12732635</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 12:13, 25 December 2014
Murine IRGa6 bound to Toxoplasma ROP5C, a pseudokinase GDI
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