3j6c
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3j6c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J6C FirstGlance]. <br> | <table><tr><td colspan='2'>[[3j6c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3J6C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3J6C FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAVS, IPS1, KIAA1271, VISA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MAVS, IPS1, KIAA1271, VISA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j6c RCSB], [http://www.ebi.ac.uk/pdbsum/3j6c PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3j6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3j6c OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3j6c RCSB], [http://www.ebi.ac.uk/pdbsum/3j6c PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MAVS_HUMAN MAVS_HUMAN]] Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.<ref>PMID:16125763</ref> <ref>PMID:16153868</ref> <ref>PMID:16177806</ref> <ref>PMID:16127453</ref> <ref>PMID:19631370</ref> <ref>PMID:20451243</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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Structural basis for the prion-like MAVS filaments in antiviral innate immunity.,Xu H, He X, Zheng H, Huang LJ, Hou F, Yu Z, de la Cruz MJ, Borkowski B, Zhang X, Chen ZJ, Jiang QX Elife. 2014 Jan 1;3:e01489. doi: 10.7554/eLife.01489. PMID:24569476<ref>PMID:24569476</ref> | Structural basis for the prion-like MAVS filaments in antiviral innate immunity.,Xu H, He X, Zheng H, Huang LJ, Hou F, Yu Z, de la Cruz MJ, Borkowski B, Zhang X, Chen ZJ, Jiang QX Elife. 2014 Jan 1;3:e01489. doi: 10.7554/eLife.01489. PMID:24569476<ref>PMID:24569476</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| - | [[Category: Borkowski, B | + | [[Category: Borkowski, B]] |
| - | [[Category: Chen, Z J | + | [[Category: Chen, Z J]] |
| - | [[Category: Cruz, M J.de la | + | [[Category: Cruz, M J.de la]] |
| - | [[Category: He, X | + | [[Category: He, X]] |
| - | [[Category: Hou, F | + | [[Category: Hou, F]] |
| - | [[Category: Huang, L J | + | [[Category: Huang, L J]] |
| - | [[Category: Jiang, Q X | + | [[Category: Jiang, Q X]] |
| - | [[Category: Xu, H | + | [[Category: Xu, H]] |
| - | [[Category: Yu, Z | + | [[Category: Yu, Z]] |
| - | [[Category: Zhang, X | + | [[Category: Zhang, X]] |
| - | [[Category: Zheng, H | + | [[Category: Zheng, H]] |
[[Category: Helical filament]] | [[Category: Helical filament]] | ||
[[Category: Innate immunity]] | [[Category: Innate immunity]] | ||
[[Category: Signaling protein]] | [[Category: Signaling protein]] | ||
Revision as of 12:17, 25 December 2014
Cryo-EM structure of MAVS CARD filament
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Categories: Human | Borkowski, B | Chen, Z J | Cruz, M J.de la | He, X | Hou, F | Huang, L J | Jiang, Q X | Xu, H | Yu, Z | Zhang, X | Zheng, H | Helical filament | Innate immunity | Signaling protein
