2juf
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2juf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUF FirstGlance]. <br> | <table><tr><td colspan='2'>[[2juf]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JUF FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PARC, H7AP1, KIAA0708 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PARC, H7AP1, KIAA0708 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2juf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2juf RCSB], [http://www.ebi.ac.uk/pdbsum/2juf PDBsum], [http://www.topsan.org/Proteins/NESGC/2juf TOPSAN]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2juf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2juf RCSB], [http://www.ebi.ac.uk/pdbsum/2juf PDBsum], [http://www.topsan.org/Proteins/NESGC/2juf TOPSAN]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/PARC_HUMAN PARC_HUMAN]] Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Dhe-Paganon, S | + | [[Category: Dhe-Paganon, S]] |
| - | [[Category: Duan, S | + | [[Category: Duan, S]] |
| - | [[Category: Edwards, A M | + | [[Category: Edwards, A M]] |
| - | [[Category: Karra, M | + | [[Category: Karra, M]] |
| - | [[Category: Kaustov, L | + | [[Category: Kaustov, L]] |
| - | [[Category: Lemak, S | + | [[Category: Lemak, S]] |
| - | [[Category: Liao, J C.C | + | [[Category: Liao, J C.C]] |
| - | [[Category: Muhandiram, R | + | [[Category: Muhandiram, R]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | + | [[Category: Srisailam, S H]] | |
| - | [[Category: Srisailam, S H | + | [[Category: Sundstrom, M]] |
| - | [[Category: Sundstrom, M | + | [[Category: Weigelt, J]] |
| - | [[Category: Weigelt, J | + | |
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
[[Category: Cph domain]] | [[Category: Cph domain]] | ||
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[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
[[Category: Nesg]] | [[Category: Nesg]] | ||
| - | [[Category: Northeast structural genomics consortium]] | ||
[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
| - | [[Category: Protein structure initiative | + | [[Category: PSI, Protein structure initiative]] |
| - | + | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomics consortium]] | ||
[[Category: Ubl conjugation pathway]] | [[Category: Ubl conjugation pathway]] | ||
[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
Revision as of 12:20, 25 December 2014
NMR solution structure of PARC CPH Domain. NESG Target HR3443B/SGC-Toronto
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Categories: Homo sapiens | Arrowsmith, C H | Dhe-Paganon, S | Duan, S | Edwards, A M | Karra, M | Kaustov, L | Lemak, S | Liao, J C.C | Muhandiram, R | Structural genomic | Srisailam, S H | Sundstrom, M | Weigelt, J | Atp-binding | Cph domain | Gene regulation | Metal-binding | Nesg | Nucleotide-binding | PSI, Protein structure initiative | Sgc | Ubl conjugation pathway | Zinc-finger
