2ns1
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2ns1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NS1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2ns1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NS1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2NS1 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u7g|1u7g]], [[1xqf|1xqf]], [[1gnk|1gnk]], [[2gnk|2gnk]], [[2b2h|2b2h]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1u7g|1u7g]], [[1xqf|1xqf]], [[1gnk|1gnk]], [[2gnk|2gnk]], [[2b2h|2b2h]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">amtB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12]), glnK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">amtB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12]), glnK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 Escherichia coli K-12])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ns1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ns1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ns1 RCSB], [http://www.ebi.ac.uk/pdbsum/2ns1 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ns1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ns1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2ns1 RCSB], [http://www.ebi.ac.uk/pdbsum/2ns1 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/AMTB_ECOLI AMTB_ECOLI]] Involved in the uptake of ammonia. [[http://www.uniprot.org/uniprot/GLNK_ECOLI GLNK_ECOLI]] P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Escherichia coli k-12]] | [[Category: Escherichia coli k-12]] | ||
| - | [[Category: CSMP, Center for Structures of Membrane Proteins | + | [[Category: CSMP, Center for Structures of Membrane Proteins]] |
| - | [[Category: Gruswitz, F | + | [[Category: Gruswitz, F]] |
| - | [[Category: III, J O.Connell | + | [[Category: III, J O.Connell]] |
| - | [[Category: Stroud, R M | + | [[Category: Stroud, R M]] |
[[Category: Adp]] | [[Category: Adp]] | ||
[[Category: Ammonia]] | [[Category: Ammonia]] | ||
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[[Category: Inhibitor]] | [[Category: Inhibitor]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
| - | [[Category: Protein structure initiative]] | + | [[Category: PSI, Protein structure initiative]] |
[[Category: Protein-protein complex]] | [[Category: Protein-protein complex]] | ||
| - | [[Category: Psi-2]] | ||
[[Category: Regulatory]] | [[Category: Regulatory]] | ||
[[Category: Signal protein]] | [[Category: Signal protein]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
[[Category: Transport protein-signaling protein complex]] | [[Category: Transport protein-signaling protein complex]] | ||
Revision as of 12:21, 25 December 2014
Crystal structure of the e. coli ammonia channel AMTB complexed with the signal transduction protein GLNK
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Categories: Escherichia coli k-12 | CSMP, Center for Structures of Membrane Proteins | Gruswitz, F | III, J O.Connell | Stroud, R M | Adp | Ammonia | Bog | Center for structures of membrane protein | Channel | Csmp | Inhibitor | Membrane protein | PSI, Protein structure initiative | Protein-protein complex | Regulatory | Signal protein | Structural genomic | Transport protein-signaling protein complex
