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2k6q
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2k6q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K6Q FirstGlance]. <br> | <table><tr><td colspan='2'>[[2k6q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2K6Q FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ugm|1ugm]], [[2zjd|2zjd]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ugm|1ugm]], [[2zjd|2zjd]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Map1lc3b, Map1alc3, Map1lc3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Map1lc3b, Map1alc3, Map1lc3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k6q RCSB], [http://www.ebi.ac.uk/pdbsum/2k6q PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2k6q RCSB], [http://www.ebi.ac.uk/pdbsum/2k6q PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MLP3B_RAT MLP3B_RAT]] Probably involved in formation of autophagosomal vacuoles (autophagosomes). [[http://www.uniprot.org/uniprot/SQSTM_RAT SQSTM_RAT]] Required both for the formation and autophagic degradation of polyubiquitin-containing bodies, called ALIS (aggresome-like induced structures). Links ALIS to the autophagic machinery via direct interaction with MAP1 LC3 family members (By similarity). May regulate the activation of NFKB1 by TNF-alpha, nerve growth factor (NGF) and interleukin-1. Adapter that mediates the interaction between TRAF6 and CYLD (By similarity). May play a role in titin/TTN downstream signaling in muscle cells. May regulate signaling cascades through ubiquitination. May be involved in cell differentiation, apoptosis, immune response and regulation of K(+) channels. Isoform 1 is more potent than isoform 2 to stimulate PRKCZ-dependent phosphorylation of KCNAB2.<ref>PMID:10477520</ref> <ref>PMID:11244088</ref> <ref>PMID:11500922</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Adachi, W | + | [[Category: Adachi, W]] |
| - | [[Category: Fujioka, Y | + | [[Category: Fujioka, Y]] |
| - | [[Category: Inagaki, F | + | [[Category: Inagaki, F]] |
| - | [[Category: Ishii, J | + | [[Category: Ishii, J]] |
| - | [[Category: Kumeta, H | + | [[Category: Kumeta, H]] |
| - | [[Category: Nakatogawa, H | + | [[Category: Nakatogawa, H]] |
| - | [[Category: Noda, N | + | [[Category: Noda, N]] |
| - | [[Category: Ohsumi, Y | + | [[Category: Ohsumi, Y]] |
| - | [[Category: Satoo, K | + | [[Category: Satoo, K]] |
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Apoptosis inhibitor-apoptosis complex]] | [[Category: Apoptosis inhibitor-apoptosis complex]] | ||
Revision as of 12:21, 25 December 2014
LC3 p62 complex structure
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Categories: Rattus norvegicus | Adachi, W | Fujioka, Y | Inagaki, F | Ishii, J | Kumeta, H | Nakatogawa, H | Noda, N | Ohsumi, Y | Satoo, K | Apoptosis | Apoptosis inhibitor-apoptosis complex | Autophagy | Cytoplasmic vesicle | Differentiation | Endosome | Immune response | Lc3 | Lipoprotein | Membrane | Metal-binding | Microtubule | Nucleus | P62 | Phosphoprotein | Ubl conjugation pathway | Zinc-finger
