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1k1v
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1k1v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K1V FirstGlance]. <br> | <table><tr><td colspan='2'>[[1k1v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K1V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K1V FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k1v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k1v RCSB], [http://www.ebi.ac.uk/pdbsum/1k1v PDBsum]</span></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k1v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1k1v RCSB], [http://www.ebi.ac.uk/pdbsum/1k1v PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MAFG_MOUSE MAFG_MOUSE]] Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF-E2. Activates globin gene expression when associated with NF-E2. May be involved in signal transduction of extracellular H(+) (By similarity).<ref>PMID:9679061</ref> <ref>PMID:16738329</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Katsuoka, F | + | [[Category: Katsuoka, F]] |
| - | [[Category: Kusunoki, H | + | [[Category: Kusunoki, H]] |
| - | [[Category: Morohashi, A | + | [[Category: Morohashi, A]] |
| - | [[Category: Motohashi, H | + | [[Category: Motohashi, H]] |
| - | [[Category: Tanaka, T | + | [[Category: Tanaka, T]] |
| - | [[Category: Yamamoto, M | + | [[Category: Yamamoto, M]] |
[[Category: Dna binding protein]] | [[Category: Dna binding protein]] | ||
[[Category: Dna-binding domain]] | [[Category: Dna-binding domain]] | ||
[[Category: Maf]] | [[Category: Maf]] | ||
[[Category: Transcription factor]] | [[Category: Transcription factor]] | ||
Revision as of 12:41, 25 December 2014
Solution Structure of the DNA-Binding Domain of MafG
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