We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
4ng6
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ng6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ng6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ng6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ng6 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ng6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ng6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ng6 RCSB], [http://www.ebi.ac.uk/pdbsum/4ng6 PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 12:45, 25 December 2014
The effects of Lysine 200 and Phenylalanine 239 Farnesyl Pyrophosphate Synthase (FPPS) mutations on the catalytic activity, crystal structure and inhibition by nitrogen containing bisphosphonates
| |||||||||||
Categories: Barnett, B L | Dunford, J E | Ebetino, F H | Evdokimov, A | Kavanagh, K L | Kwaasi, A A | Muniz, J R.C | Oppermann, U | Pilka, E | Russell, R G.G | Tsoumpra, M K | Walter, R L | Alpha-helical prenyltransferase | Bisphosphonate | Cholesterol synthesis | Isoprene biosynthesis | Isoprenoid pathway | Lipid synthesis | Steroid biosynthesis | Transferase
