2crc
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2crc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2crc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2crc RCSB], [http://www.ebi.ac.uk/pdbsum/2crc PDBsum], [http://www.topsan.org/Proteins/RSGI/2crc TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2crc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2crc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2crc RCSB], [http://www.ebi.ac.uk/pdbsum/2crc PDBsum], [http://www.topsan.org/Proteins/RSGI/2crc TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/UB7I3_HUMAN UB7I3_HUMAN]] E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('M-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. Binds polyubiquitin of different linkage types.<ref>PMID:12629548</ref> <ref>PMID:17006537</ref> <ref>PMID:17449468</ref> <ref>PMID:18711448</ref> <ref>PMID:20005846</ref> <ref>PMID:19136968</ref> <ref>PMID:21455173</ref> <ref>PMID:21455180</ref> <ref>PMID:21455181</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Hayashi, F | + | [[Category: Hayashi, F]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Yokoyama, S | + | [[Category: Yokoyama, S]] |
| - | [[Category: Zhang, H P | + | [[Category: Zhang, H P]] |
[[Category: Hbv associated factor 4]] | [[Category: Hbv associated factor 4]] | ||
[[Category: Hepatitis b virus x-associated protein 4]] | [[Category: Hepatitis b virus x-associated protein 4]] | ||
| Line 19: | Line 23: | ||
[[Category: National project on protein structural and functional analyse]] | [[Category: National project on protein structural and functional analyse]] | ||
[[Category: Nppsfa]] | [[Category: Nppsfa]] | ||
| - | [[Category: Riken structural genomics/proteomics initiative]] | ||
[[Category: Rsgi]] | [[Category: Rsgi]] | ||
| - | [[Category: Structural genomic]] | ||
[[Category: Ubiquitin conjugating enzyme 7 interacting protein 3]] | [[Category: Ubiquitin conjugating enzyme 7 interacting protein 3]] | ||
[[Category: Zf-ranbp domain]] | [[Category: Zf-ranbp domain]] | ||
Revision as of 12:48, 25 December 2014
Solution structure of the zf-RanBP domain of the protein HBV associated factor
| |||||||||||
Categories: Homo sapiens | Hayashi, F | Structural genomic | Yokoyama, S | Zhang, H P | Hbv associated factor 4 | Hepatitis b virus x-associated protein 4 | Ligase | National project on protein structural and functional analyse | Nppsfa | Rsgi | Ubiquitin conjugating enzyme 7 interacting protein 3 | Zf-ranbp domain
