3nv0
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3nv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NV0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[3nv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NV0 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C15H11.6, nxf-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans]), nxt-1, nxt1, Y71F9AM.5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C15H11.6, nxf-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans]), nxt-1, nxt1, Y71F9AM.5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nv0 RCSB], [http://www.ebi.ac.uk/pdbsum/3nv0 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3nv0 RCSB], [http://www.ebi.ac.uk/pdbsum/3nv0 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NXF2_CAEEL NXF2_CAEEL]] May be involved in the export of cellular mRNA to the cytoplasm (By similarity). [[http://www.uniprot.org/uniprot/NXT1_CAEEL NXT1_CAEEL]] Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold.,Kerkow DE, Carmel AB, Menichelli E, Ambrus G, Hills RD Jr, Gerace L, Williamson JR J Mol Biol. 2012 Jan 27;415(4):649-65. doi: 10.1016/j.jmb.2011.11.027. Epub 2011 , Nov 22. PMID:22123199<ref>PMID:22123199</ref> | The structure of the NXF2/NXT1 heterodimeric complex reveals the combined specificity and versatility of the NTF2-like fold.,Kerkow DE, Carmel AB, Menichelli E, Ambrus G, Hills RD Jr, Gerace L, Williamson JR J Mol Biol. 2012 Jan 27;415(4):649-65. doi: 10.1016/j.jmb.2011.11.027. Epub 2011 , Nov 22. PMID:22123199<ref>PMID:22123199</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
== References == | == References == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Caenorhabditis elegans]] | [[Category: Caenorhabditis elegans]] | ||
| - | [[Category: Carmel, A B | + | [[Category: Carmel, A B]] |
| - | [[Category: Kerkow, D E | + | [[Category: Kerkow, D E]] |
| - | [[Category: Williamson, J R | + | [[Category: Williamson, J R]] |
[[Category: Beta sheet heterodimer interface]] | [[Category: Beta sheet heterodimer interface]] | ||
[[Category: Cation-pi interaction]] | [[Category: Cation-pi interaction]] | ||
Revision as of 12:50, 25 December 2014
Crystal structure and mutational analysis of the NXF2/NXT1 heterodimeric complex from caenorhabditis elegans at 1.84 A resolution
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Categories: Caenorhabditis elegans | Carmel, A B | Kerkow, D E | Williamson, J R | Beta sheet heterodimer interface | Cation-pi interaction | Intramonomer buried water | Mrna transport | Novel surface exposed pocket | Ntf2-like domain | Ntf2-plug | Nucleoporin binding pocket | Nucleus | Nxf-loop | Pi-pi interaction | Rna binding-protein transport complex | Rna-binding | Water mediated interface
