2xpx
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xpx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xpx RCSB], [http://www.ebi.ac.uk/pdbsum/2xpx PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xpx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xpx RCSB], [http://www.ebi.ac.uk/pdbsum/2xpx PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/EAR_EBVB9 EAR_EBVB9]] Prevents premature death of the host cell during virus production, which would otherwise reduce the amount of progeny virus. Acts as a host B-cell leukemia/lymphoma 2 (Bcl-2) homolog, and interacts with pro-apoptotic proteins to prevent mitochondria permeabilization, release of cytochrome c and subsequent apoptosis of the host cell. [[http://www.uniprot.org/uniprot/BAK_HUMAN BAK_HUMAN]] In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.<ref>PMID:8521816</ref> <ref>PMID:17157251</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Human herpesvirus 4]] | [[Category: Human herpesvirus 4]] | ||
| - | [[Category: Colman, P M | + | [[Category: Colman, P M]] |
| - | [[Category: Huang, D C.S | + | [[Category: Huang, D C.S]] |
| - | [[Category: Kvansakul, M | + | [[Category: Kvansakul, M]] |
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Membrane protein]] | [[Category: Membrane protein]] | ||
Revision as of 12:50, 25 December 2014
Crystal structure of BHRF1:Bak BH3 complex
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