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3u3v
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3u3v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U3V FirstGlance]. <br> | <table><tr><td colspan='2'>[[3u3v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U3V FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u3p|3u3p]], [[3u3q|3u3q]], [[3u3s|3u3s]], [[3u3t|3u3t]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u3p|3u3p]], [[3u3q|3u3q]], [[3u3s|3u3s]], [[3u3t|3u3t]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFRSF21, DR6, UNQ437/PRO868 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFRSF21, DR6, UNQ437/PRO868 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u3v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u3v RCSB], [http://www.ebi.ac.uk/pdbsum/3u3v PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u3v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u3v RCSB], [http://www.ebi.ac.uk/pdbsum/3u3v PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TNR21_HUMAN TNR21_HUMAN]] May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 13: | Line 15: | ||
S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS.,Ru H, Zhao L, Ding W, Jiao L, Shaw N, Liang W, Zhang L, Hung LW, Matsugaki N, Wakatsuki S, Liu ZJ Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):521-30. Epub 2012 Apr 17. PMID:22525750<ref>PMID:22525750</ref> | S-SAD phasing study of death receptor 6 and its solution conformation revealed by SAXS.,Ru H, Zhao L, Ding W, Jiao L, Shaw N, Liang W, Zhang L, Hung LW, Matsugaki N, Wakatsuki S, Liu ZJ Acta Crystallogr D Biol Crystallogr. 2012 May;68(Pt 5):521-30. Epub 2012 Apr 17. PMID:22525750<ref>PMID:22525750</ref> | ||
| - | From | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> |
</div> | </div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Tumor necrosis factor receptor|Tumor necrosis factor receptor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Ding, W | + | [[Category: Ding, W]] |
| - | [[Category: Hung, L W | + | [[Category: Hung, L W]] |
| - | [[Category: Jiao, L Y | + | [[Category: Jiao, L Y]] |
| - | [[Category: Liu, Z J | + | [[Category: Liu, Z J]] |
| - | [[Category: Matsugaki, N | + | [[Category: Matsugaki, N]] |
| - | [[Category: Ru, H | + | [[Category: Ru, H]] |
| - | [[Category: Shaw, N | + | [[Category: Shaw, N]] |
| - | [[Category: Wakatsuki, S | + | [[Category: Wakatsuki, S]] |
| - | [[Category: Zhang, L G | + | [[Category: Zhang, L G]] |
| - | [[Category: Zhao, L X | + | [[Category: Zhao, L X]] |
[[Category: Apoptosis]] | [[Category: Apoptosis]] | ||
[[Category: Trigger apoptosis]] | [[Category: Trigger apoptosis]] | ||
Revision as of 12:53, 25 December 2014
The S-SAD phased crystal structure of the ecto-domain of Death Receptor 6 (DR6)
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Categories: Homo sapiens | Ding, W | Hung, L W | Jiao, L Y | Liu, Z J | Matsugaki, N | Ru, H | Shaw, N | Wakatsuki, S | Zhang, L G | Zhao, L X | Apoptosis | Trigger apoptosis
