3l9i
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l9i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l9i RCSB], [http://www.ebi.ac.uk/pdbsum/3l9i PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l9i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l9i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l9i RCSB], [http://www.ebi.ac.uk/pdbsum/3l9i PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref> [[http://www.uniprot.org/uniprot/CALM_DROME CALM_DROME]] Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. | ||
==See Also== | ==See Also== | ||
*[[Myosin|Myosin]] | *[[Myosin|Myosin]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 13:00, 25 December 2014
Myosin VI nucleotide-free (mdinsert2) L310G mutant crystal structure
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Categories: Drosophila melanogaster | Sus scrofa | Houdusse, A | Pylypenko, O | Song, L | Sweeney, L H | Actin-binding | Atp-binding | Calmodulin-binding | Directionality | Endocytosis | Gating | Golgi apparatus | Hearing | Membrane | Motility | Motor protein | Myosin | Myosin vi | Nucleotide-binding | Nucleus | Phosphoprotein | Protein transport | Transport | Unconventional myosin
