4cqx

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4cqx]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CQX FirstGlance]. <br>
<table><tr><td colspan='2'>[[4cqx]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CQX FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cqp|4cqp]], [[4cqq|4cqq]], [[4cqr|4cqr]], [[4cqs|4cqs]], [[4cqt|4cqt]], [[4cqu|4cqu]], [[4cqv|4cqv]], [[4cqw|4cqw]], [[4cqy|4cqy]], [[4cqz|4cqz]], [[4cr0|4cr0]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cqp|4cqp]], [[4cqq|4cqq]], [[4cqr|4cqr]], [[4cqs|4cqs]], [[4cqt|4cqt]], [[4cqu|4cqu]], [[4cqv|4cqv]], [[4cqw|4cqw]], [[4cqy|4cqy]], [[4cqz|4cqz]], [[4cr0|4cr0]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cqx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cqx RCSB], [http://www.ebi.ac.uk/pdbsum/4cqx PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cqx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cqx RCSB], [http://www.ebi.ac.uk/pdbsum/4cqx PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/Q207Z6_9INFA Q207Z6_9INFA]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore (By similarity).[RuleBase:RU003324][SAAS:SAAS008980_004_327643]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Collins, P J.]]
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[[Category: Collins, P J]]
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[[Category: Coombs, P J.]]
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[[Category: Coombs, P J]]
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[[Category: Gamblin, S J.]]
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[[Category: Gamblin, S J]]
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[[Category: Lin, Y P.]]
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[[Category: Lin, Y P]]
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[[Category: Liu, J.]]
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[[Category: Liu, J]]
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[[Category: Martin, S R.]]
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[[Category: Martin, S R]]
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[[Category: McCauley, J W.]]
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[[Category: McCauley, J W]]
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[[Category: Skehel, J J.]]
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[[Category: Skehel, J J]]
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[[Category: Vachieri, S G.]]
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[[Category: Vachieri, S G]]
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[[Category: Walker, P A.]]
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[[Category: Walker, P A]]
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[[Category: Xiao, H.]]
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[[Category: Xiao, H]]
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[[Category: Xiong, X.]]
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[[Category: Xiong, X]]
[[Category: 3'sln]]
[[Category: 3'sln]]
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[[Category: 3sln]]
 
[[Category: 6'sln]]
[[Category: 6'sln]]
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[[Category: 6sln]]
 
[[Category: Avian flu]]
[[Category: Avian flu]]
[[Category: Glycoprotein]]
[[Category: Glycoprotein]]

Revision as of 13:03, 25 December 2014

H5 (tyTy) Del133/Ile155Thr Mutant Haemagglutinin in Complex with Human Receptor Analogue 6'SLN

4cqx, resolution 2.30Å

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