3uro

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3uro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3eow 3eow]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3URO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3URO FirstGlance]. <br>
<table><tr><td colspan='2'>[[3uro]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3eow 3eow]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3URO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3URO FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3epc|3epc]], [[3epd|3epd]], [[3epf|3epf]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3epc|3epc]], [[3epd|3epd]], [[3epf|3epf]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PVR, PVS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PVR, PVS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uro OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uro RCSB], [http://www.ebi.ac.uk/pdbsum/3uro PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3uro FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3uro OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3uro RCSB], [http://www.ebi.ac.uk/pdbsum/3uro PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PVR_HUMAN PVR_HUMAN]] Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.<ref>PMID:15471548</ref> <ref>PMID:15607800</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses.,Zhang P, Mueller S, Morais MC, Bator CM, Bowman VD, Hafenstein S, Wimmer E, Rossmann MG Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18284-9. Epub 2008 Nov 14. PMID:19011098<ref>PMID:19011098</ref>
Crystal structure of CD155 and electron microscopic studies of its complexes with polioviruses.,Zhang P, Mueller S, Morais MC, Bator CM, Bowman VD, Hafenstein S, Wimmer E, Rossmann MG Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18284-9. Epub 2008 Nov 14. PMID:19011098<ref>PMID:19011098</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
== References ==
== References ==
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Bator, C M.]]
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[[Category: Bator, C M]]
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[[Category: Bowman, V D.]]
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[[Category: Bowman, V D]]
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[[Category: Hafenstein, S.]]
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[[Category: Hafenstein, S]]
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[[Category: Morais, M C.]]
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[[Category: Morais, M C]]
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[[Category: Mueller, S.]]
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[[Category: Mueller, S]]
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[[Category: Rossmann, M G.]]
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[[Category: Rossmann, M G]]
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[[Category: Wimmer, E.]]
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[[Category: Wimmer, E]]
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[[Category: Zhang, P.]]
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[[Category: Zhang, P]]
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]
[[Category: Cell membrane]]
[[Category: Cell membrane]]

Revision as of 13:03, 25 December 2014

Poliovirus receptor CD155 D1D2

3uro, resolution 3.50Å

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