4ifh
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ifh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ifh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ifh RCSB], [http://www.ebi.ac.uk/pdbsum/4ifh PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ifh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ifh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4ifh RCSB], [http://www.ebi.ac.uk/pdbsum/4ifh PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | ||
==See Also== | ==See Also== | ||
*[[Insulin-Degrading Enzyme|Insulin-Degrading Enzyme]] | *[[Insulin-Degrading Enzyme|Insulin-Degrading Enzyme]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 13:05, 25 December 2014
Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619
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