1imi
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1imi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_imperialis Conus imperialis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IMI FirstGlance]. <br> | <table><tr><td colspan='2'>[[1imi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Conus_imperialis Conus imperialis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IMI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1IMI FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1imi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1imi RCSB], [http://www.ebi.ac.uk/pdbsum/1imi PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1imi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1imi OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1imi RCSB], [http://www.ebi.ac.uk/pdbsum/1imi PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CXA1_CONIM CXA1_CONIM]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian neuronal nAChRs (alpha-3/beta-2 > alpha-7 > alpha-3/beta-4). Has no effect on nAChRs composed of alpha-2/beta-2, alpha-3/beta-2, alpha-4/beta-2, alpha-2/beta-4, alpha-3/beta-4, or alpha-4/beta-4 subunits. Acts voltage-independently. Is highly active against the neuromuscular receptor in frog.<ref>PMID:8206995</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 19: | Line 21: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Conus imperialis]] | [[Category: Conus imperialis]] | ||
| - | [[Category: Arseniev, A S | + | [[Category: Arseniev, A S]] |
| - | [[Category: Ivanov, V T | + | [[Category: Ivanov, V T]] |
| - | [[Category: Maslennikov, I V | + | [[Category: Maslennikov, I V]] |
| - | [[Category: Shenkarev, Z O | + | [[Category: Shenkarev, Z O]] |
| - | [[Category: Tsetlin, V I | + | [[Category: Tsetlin, V I]] |
| - | [[Category: Zhmak, M N | + | [[Category: Zhmak, M N]] |
[[Category: Acetylcholine receptor inhibitor]] | [[Category: Acetylcholine receptor inhibitor]] | ||
[[Category: Antagonist]] | [[Category: Antagonist]] | ||
Revision as of 13:07, 25 December 2014
SOLUTION STRUCTURE OF ALPHA-CONOTOXIN IM1
| |||||||||||
