1o6y

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Revision as of 14:51, 29 October 2007

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spinqualitylabelsall models 1o6y, resolution 2.2Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CATALYTIC DOMAIN OF PKNB KINASE FROM MYCOBACTERIUM TUBERCULOSIS

Overview

With the advent of the sequencing programs of prokaryotic genomes, many, examples of the presence of serine/threonine protein kinases in these, organisms have been identified. Moreover, these kinases could be, classified as homologues of those belonging to the well characterized, superfamily of the eukaryotic serine/threonine and tyrosine kinases., Eleven such kinases were recognized in the genome of Mycobacterium, tuberculosis. Here we report the crystal structure of an active form of, PknB, one of the four M. tuberculosis kinases that are conserved in the, downsized genome of Mycobacterium leprae and are therefore presumed to, play an important role in the processes that regulate the complex life, cycle of mycobacteria. Our structure confirms again the extraordinary, conservation of the ... [(full description)]

About this Structure

1O6Y is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with MG and ACP as [ligands]. Active as [[1]], with EC number [2.7.1.37]. Full crystallographic information is available from [OCA].

Reference

Crystal structure of the catalytic domain of the PknB serine/threonine kinase from Mycobacterium tuberculosis., Ortiz-Lombardia M, Pompeo F, Boitel B, Alzari PM, J Biol Chem. 2003 Apr 11;278(15):13094-100. Epub 2003 Jan 27. PMID:12551895

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