1t3j

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1t3j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T3J FirstGlance]. <br>
<table><tr><td colspan='2'>[[1t3j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1T3J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1T3J FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MFN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MFN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t3j RCSB], [http://www.ebi.ac.uk/pdbsum/1t3j PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1t3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1t3j OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1t3j RCSB], [http://www.ebi.ac.uk/pdbsum/1t3j PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MFN1_MOUSE MFN1_MOUSE]] Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.<ref>PMID:12527753</ref> <ref>PMID:15297672</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Chan, D C.]]
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[[Category: Chan, D C]]
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[[Category: Chen, H.]]
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[[Category: Chen, H]]
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[[Category: Detmer, S A.]]
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[[Category: Detmer, S A]]
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[[Category: Kaiser, J T.]]
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[[Category: Kaiser, J T]]
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[[Category: Koshiba, T.]]
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[[Category: Koshiba, T]]
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[[Category: McCaffery, J M.]]
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[[Category: McCaffery, J M]]
[[Category: Coiled coil antiparallel]]
[[Category: Coiled coil antiparallel]]
[[Category: Dimer]]
[[Category: Dimer]]
[[Category: Membrane protein]]
[[Category: Membrane protein]]

Revision as of 13:13, 25 December 2014

Mitofusin domain HR2 V686M/I708M mutant

1t3j, resolution 2.50Å

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