4qxu
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qxu RCSB], [http://www.ebi.ac.uk/pdbsum/4qxu PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qxu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qxu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qxu RCSB], [http://www.ebi.ac.uk/pdbsum/4qxu PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MMP14_HUMAN MMP14_HUMAN]] Seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15.<ref>PMID:20837484</ref> <ref>PMID:22065321</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 13:15, 25 December 2014
Novel Inhibition Mechanism of Membrane Metalloprotease by an Exosite-Swiveling Conformational antibody
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Categories: Membrane-type matrix metalloproteinase-1 | Arroyo, A G | Cuiniasse, P | Dive, V | Dym, O | Grossman, M | ISPC, Israel Structural Proteomics Center | Moreno, v | Rozenberg, H | Sagi, I | Solomonov, I | Udi, Y | Igg fold | Immune system | PSI, Protein structure initiative | Structural genomic
