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2zhp
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2zhp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptoalloteichus_hindustanus Streptoalloteichus hindustanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZHP FirstGlance]. <br> | <table><tr><td colspan='2'>[[2zhp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptoalloteichus_hindustanus Streptoalloteichus hindustanus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZHP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZHP FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BY6:[(2S,3R,4R,5S,6S)-2-[(3R,4R,5R,6R)-2-[(1R,2S)-2-[[6-AMINO-2-[(1S)-3-AMINO-1-[(2,3-DIAMINO-3-OXOPROPYL)AMINO]-3-OXOPROPYL]-5-METHYLPYRIMIDINE-4-CARBONYL]AMINO]-3-[[(2S,3R,4R)-5-[[(2R,3S)-1-[2-[4-[4-[3-[4-(3-AMINOPROPYLAMINO)BUTYLAMINO]PROPYLCARBAMOYL]-1,3-THIAZOL-2-YL]-1,3-THIAZOL-2-YL]ETHYLAMINO]-3-HYDROXY-1-OXOBUTAN-2-YL]AMINO]-3-HYDROXY-4-METHYL-5-OXOPENTAN-2-YL]AMINO]-1-(3H-IMIDAZOL-4-YL)-3-OXOPROPOXY]-4,5-DIHYDROXY-6-(HYDROXYMETHYL)OXAN-3-YL]OXY-3,5-DIHYDROXY-6-(HYDROXYMETHYL)OXAN-4-YL]+CARBAMATE'>BY6</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BY6:[(2S,3R,4R,5S,6S)-2-[(3R,4R,5R,6R)-2-[(1R,2S)-2-[[6-AMINO-2-[(1S)-3-AMINO-1-[(2,3-DIAMINO-3-OXOPROPYL)AMINO]-3-OXOPROPYL]-5-METHYLPYRIMIDINE-4-CARBONYL]AMINO]-3-[[(2S,3R,4R)-5-[[(2R,3S)-1-[2-[4-[4-[3-[4-(3-AMINOPROPYLAMINO)BUTYLAMINO]PROPYLCARBAMOYL]-1,3-THIAZOL-2-YL]-1,3-THIAZOL-2-YL]ETHYLAMINO]-3-HYDROXY-1-OXOBUTAN-2-YL]AMINO]-3-HYDROXY-4-METHYL-5-OXOPENTAN-2-YL]AMINO]-1-(3H-IMIDAZOL-4-YL)-3-OXOPROPOXY]-4,5-DIHYDROXY-6-(HYDROXYMETHYL)OXAN-3-YL]OXY-3,5-DIHYDROXY-6-(HYDROXYMETHYL)OXAN-4-YL]+CARBAMATE'>BY6</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1byl|1byl]], [[1xrk|1xrk]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1byl|1byl]], [[1xrk|1xrk]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zhp RCSB], [http://www.ebi.ac.uk/pdbsum/2zhp PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zhp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zhp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zhp RCSB], [http://www.ebi.ac.uk/pdbsum/2zhp PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BLE_STRHI BLE_STRHI]] Binding protein with a strong affinity to the bleomycin family of antibiotics. | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Streptoalloteichus hindustanus]] | [[Category: Streptoalloteichus hindustanus]] | ||
| - | [[Category: Miyazaki, I | + | [[Category: Miyazaki, I]] |
| - | [[Category: Okumura, H | + | [[Category: Okumura, H]] |
| - | [[Category: Osada, H | + | [[Category: Osada, H]] |
| - | [[Category: Simizu, S | + | [[Category: Simizu, S]] |
[[Category: Antibiotic inhibitor]] | [[Category: Antibiotic inhibitor]] | ||
[[Category: Antibiotic resistance]] | [[Category: Antibiotic resistance]] | ||
[[Category: Bleomycin]] | [[Category: Bleomycin]] | ||
[[Category: Ligand binding protein]] | [[Category: Ligand binding protein]] | ||
Revision as of 13:16, 25 December 2014
Crystal structure of bleomycin-binding protein from Streptoalloteichus hindustanus complexed with bleomycin derivative
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