3ilc

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ilc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ilc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ilc RCSB], [http://www.ebi.ac.uk/pdbsum/3ilc PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ilc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ilc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ilc RCSB], [http://www.ebi.ac.uk/pdbsum/3ilc PDBsum]</span></td></tr>
</table>
</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/B2CL1_MOUSE B2CL1_MOUSE]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:9390687</ref> Isoform Bcl-X(S) promotes apoptosis (By similarity).<ref>PMID:9390687</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]

Revision as of 13:17, 25 December 2014

Crystal structure of mouse Bcl-xl mutant (Y101A) at pH 6.0

3ilc, resolution 1.64Å

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