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1jyr
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1jyr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYR FirstGlance]. <br> | <table><tr><td colspan='2'>[[1jyr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JYR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1JYR FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jyq|1jyq]], [[1jyu|1jyu]]</td></tr> | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1jyq|1jyq]], [[1jyu|1jyu]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jyr RCSB], [http://www.ebi.ac.uk/pdbsum/1jyr PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1jyr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jyr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1jyr RCSB], [http://www.ebi.ac.uk/pdbsum/1jyr PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN]] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Broutin, I | + | [[Category: Broutin, I]] |
| - | [[Category: Charbonnier, F | + | [[Category: Charbonnier, F]] |
| - | [[Category: Ducruix, A | + | [[Category: Ducruix, A]] |
| - | [[Category: Garbay, C | + | [[Category: Garbay, C]] |
| - | [[Category: Latreille, M T | + | [[Category: Latreille, M T]] |
| - | [[Category: Liu, W Q | + | [[Category: Liu, W Q]] |
| - | [[Category: Nioche, P | + | [[Category: Nioche, P]] |
| - | [[Category: Roques, B | + | [[Category: Roques, B]] |
| - | [[Category: Vidal, M | + | [[Category: Vidal, M]] |
[[Category: Inhibitor]] | [[Category: Inhibitor]] | ||
[[Category: Receptor binding]] | [[Category: Receptor binding]] | ||
[[Category: Regulatory]] | [[Category: Regulatory]] | ||
[[Category: Signaling protein-inhibitor complex]] | [[Category: Signaling protein-inhibitor complex]] | ||
Revision as of 13:21, 25 December 2014
Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide
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