2jeu

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2jeu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEU FirstGlance]. <br>
<table><tr><td colspan='2'>[[2jeu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bovine_papillomavirus_type_1 Bovine papillomavirus type 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2JEU FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dbd|1dbd]], [[1jjh|1jjh]], [[2bop|2bop]]</td></tr>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1dbd|1dbd]], [[1jjh|1jjh]], [[2bop|2bop]]</td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jeu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jeu RCSB], [http://www.ebi.ac.uk/pdbsum/2jeu PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jeu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jeu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2jeu RCSB], [http://www.ebi.ac.uk/pdbsum/2jeu PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/VE2_BPV1 VE2_BPV1]] E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Bovine papillomavirus type 1]]
[[Category: Bovine papillomavirus type 1]]
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[[Category: Antson, A A.]]
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[[Category: Antson, A A]]
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[[Category: Ortiz-Lombardia, M.]]
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[[Category: Ortiz-Lombardia, M]]
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[[Category: Sanders, C M.]]
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[[Category: Sanders, C M]]
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[[Category: Seavers, P R.]]
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[[Category: Seavers, P R]]
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[[Category: Sizov, D.]]
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[[Category: Sizov, D]]
[[Category: Activator]]
[[Category: Activator]]
[[Category: Bovine papillomavirus]]
[[Category: Bovine papillomavirus]]

Revision as of 13:22, 25 December 2014

TRANSCRIPTION ACTIVATOR STRUCTURE REVEALS REDOX CONTROL OF A REPLICATION INITIATION REACTION

2jeu, resolution 2.80Å

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