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2bk2
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2bk2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BK2 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2bk2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_perfringens Clostridium perfringens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BK2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2BK2 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1m3i|1m3i]], [[1m3j|1m3j]], [[1pfo|1pfo]], [[2bk1|2bk1]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1m3i|1m3i]], [[1m3j|1m3j]], [[1pfo|1pfo]], [[2bk1|2bk1]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bk2 RCSB], [http://www.ebi.ac.uk/pdbsum/2bk2 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bk2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2bk2 RCSB], [http://www.ebi.ac.uk/pdbsum/2bk2 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TACY_CLOPE TACY_CLOPE]] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein assembles into a pre-pore complex. A conformation change leads to insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host cell membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation.<ref>PMID:17328912</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Clostridium perfringens]] | [[Category: Clostridium perfringens]] | ||
| - | [[Category: Andrew, P W | + | [[Category: Andrew, P W]] |
| - | [[Category: Gilbert, R J.C | + | [[Category: Gilbert, R J.C]] |
| - | [[Category: Orlova, E V | + | [[Category: Orlova, E V]] |
| - | [[Category: Saibil, H R | + | [[Category: Saibil, H R]] |
| - | [[Category: Tilley, S J | + | [[Category: Tilley, S J]] |
[[Category: Cryoem]] | [[Category: Cryoem]] | ||
[[Category: Cytolysis]] | [[Category: Cytolysis]] | ||
Revision as of 13:39, 25 December 2014
The prepore structure of pneumolysin, obtained by fitting the alpha carbon trace of perfringolysin O into a cryo-EM map
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