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2v0p
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v0p RCSB], [http://www.ebi.ac.uk/pdbsum/2v0p PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2v0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v0p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2v0p RCSB], [http://www.ebi.ac.uk/pdbsum/2v0p PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TAP42_YEAST TAP42_YEAST]] Involved in negative regulation of the TOR signaling pathway in response to type of available nitrogen source. Inhibitor of PP2A phosphatase SIT4, which results in inhibition of nuclear export of MSN2, due to lack of dephosphorylation by SIT4. Also required for rapamycin induced activation of expression of many nitrogen discrimination pathway (NDP) genes. In complex with PPH21, required for organization of the actin cytoskeletom during the cell cycle via a Rho GTPase-dependent mechanism.<ref>PMID:14551259</ref> <ref>PMID:12820961</ref> <ref>PMID:12697813</ref> <ref>PMID:15470255</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
| - | [[Category: Barford, D | + | [[Category: Barford, D]] |
| - | [[Category: Roe, S M | + | [[Category: Roe, S M]] |
| - | [[Category: Yang, J | + | [[Category: Yang, J]] |
[[Category: Hydrolase inhibitor]] | [[Category: Hydrolase inhibitor]] | ||
[[Category: Phosphorylation]] | [[Category: Phosphorylation]] | ||
[[Category: Signal transduction inhibitor]] | [[Category: Signal transduction inhibitor]] | ||
Revision as of 13:45, 25 December 2014
THE STRUCTURE OF TAP42 ALPHA4 SUBUNIT
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