2l0z
From Proteopedia
(Difference between revisions)
| Line 7: | Line 7: | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l0z RCSB], [http://www.ebi.ac.uk/pdbsum/2l0z PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l0z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2l0z RCSB], [http://www.ebi.ac.uk/pdbsum/2l0z PDBsum]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/GLYC_JUNIN GLYC_JUNIN]] Stable signal peptide (SSP) is cleaved but is apparently retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational cleavage of GP1 and GP2, glycoprotein transport to the cell plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion (By similarity). Glycoprotein G1 mediates virus attachment to host TFRC. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.<ref>PMID:19548229</ref> Glycoprotein G2 is a class I viral fusion protein, that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversable conformational changes induced upon acidification in the endosome (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 19: | Line 21: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Briknarova, K | + | [[Category: Briknarova, K]] |
| - | [[Category: Nunberg, J H | + | [[Category: Nunberg, J H]] |
| - | [[Category: York, J | + | [[Category: York, J]] |
[[Category: Arenavirus]] | [[Category: Arenavirus]] | ||
[[Category: Gpc]] | [[Category: Gpc]] | ||
Revision as of 13:53, 25 December 2014
Solution structure of a zinc-binding domain from the Junin virus envelope glycoprotein
| |||||||||||
