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1kv0
From Proteopedia
(Difference between revisions)
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1kv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KV0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1kv0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mesobuthus_martensii Mesobuthus martensii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KV0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KV0 FirstGlance]. <br> | ||
| - | </td></tr><tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sn1|1sn1]], [[1sn4|1sn4]], [[1chz|1chz]], [[1djt|1djt]]</td></tr> | + | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1sn1|1sn1]], [[1sn4|1sn4]], [[1chz|1chz]], [[1djt|1djt]]</td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kv0 RCSB], [http://www.ebi.ac.uk/pdbsum/1kv0 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kv0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kv0 RCSB], [http://www.ebi.ac.uk/pdbsum/1kv0 PDBsum]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SCX7_MESMA SCX7_MESMA]] Binds to sodium channels (Nav) and inhibits the inactivation of the activated channels, thereby blocking neuronal transmission. Is active on both mammals and insects. Can be considered as a cardiotoxin, as it can bind to human cardiac sodium channel and modify its normal properties.<ref>PMID:12370033</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Mesobuthus martensii]] | [[Category: Mesobuthus martensii]] | ||
| - | [[Category: Guan, R J | + | [[Category: Guan, R J]] |
| - | [[Category: He, X L | + | [[Category: He, X L]] |
| - | [[Category: Wang, D C | + | [[Category: Wang, D C]] |
| - | [[Category: Wang, M | + | [[Category: Wang, M]] |
| - | [[Category: Xiang, Y | + | [[Category: Xiang, Y]] |
[[Category: Cis/trans isomerization]] | [[Category: Cis/trans isomerization]] | ||
[[Category: Dimeric structure]] | [[Category: Dimeric structure]] | ||
Revision as of 13:58, 25 December 2014
Cis/trans Isomerization of Non-prolyl Peptide Bond Observed in Crystal Structure of an Scorpion Toxin
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