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2zio

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2zio]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_mazei Methanosarcina mazei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZIO FirstGlance]. <br>
<table><tr><td colspan='2'>[[2zio]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Methanosarcina_mazei Methanosarcina mazei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ZIO FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PN:IMIDODIPHOSPHORIC+ACID'>2PN</scene>, <scene name='pdbligand=AYB:5-O-[(S)-({(2S)-2-AMINO-6-[(PROPOXYCARBONYL)AMINO]HEXANOYL}OXY)(HYDROXY)PHOSPHORYL]ADENOSINE'>AYB</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2PN:IMIDODIPHOSPHORIC+ACID'>2PN</scene>, <scene name='pdbligand=AYB:5-O-[(S)-({(2S)-2-AMINO-6-[(PROPOXYCARBONYL)AMINO]HEXANOYL}OXY)(HYDROXY)PHOSPHORYL]ADENOSINE'>AYB</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2e3c|2e3c]], [[2zcd|2zcd]], [[2zce|2zce]], [[2zin|2zin]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2e3c|2e3c]], [[2zcd|2zcd]], [[2zce|2zce]], [[2zin|2zin]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pylS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2209 Methanosarcina mazei])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pylS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2209 Methanosarcina mazei])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyrrolysine--tRNA(Pyl)_ligase Pyrrolysine--tRNA(Pyl) ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.26 6.1.1.26] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyrrolysine--tRNA(Pyl)_ligase Pyrrolysine--tRNA(Pyl) ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.26 6.1.1.26] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zio OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zio RCSB], [http://www.ebi.ac.uk/pdbsum/2zio PDBsum], [http://www.topsan.org/Proteins/RSGI/2zio TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2zio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zio OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2zio RCSB], [http://www.ebi.ac.uk/pdbsum/2zio PDBsum], [http://www.topsan.org/Proteins/RSGI/2zio TOPSAN]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PYLS_METMA PYLS_METMA]] Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Methanosarcina mazei]]
[[Category: Methanosarcina mazei]]
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[[Category: Ishii, R.]]
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[[Category: Ishii, R]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Structural genomic]]
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[[Category: Yanagisawa, T.]]
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[[Category: Yanagisawa, T]]
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[[Category: Yokoyama, S.]]
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[[Category: Yokoyama, S]]
[[Category: Aminoacyl-trna synthetase]]
[[Category: Aminoacyl-trna synthetase]]
[[Category: Atp analogue]]
[[Category: Atp analogue]]
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[[Category: Pyrrolysine]]
[[Category: Pyrrolysine]]
[[Category: Pyrrolysyl-trna synthetase]]
[[Category: Pyrrolysyl-trna synthetase]]
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[[Category: Riken structural genomics/proteomics initiative]]
 
[[Category: Rsgi]]
[[Category: Rsgi]]
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[[Category: Structural genomic]]
 
[[Category: Trna]]
[[Category: Trna]]
[[Category: Unnatural amino acid]]
[[Category: Unnatural amino acid]]

Revision as of 13:58, 25 December 2014

Crystal structure of the catalytic domain of pyrrolysyl-tRNA synthetase in complex with AlocLys-AMP and PNP

2zio, resolution 2.06Å

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