3r0i

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3r0i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R0I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R0I FirstGlance]. <br>
<table><tr><td colspan='2'>[[3r0i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R0I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3R0I FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C0K:{(1S)-1-(3,4-DIFLUOROPHENYL)-4-[HYDROXY(METHYL)AMINO]-4-OXOBUTYL}PHOSPHONIC+ACID'>C0K</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene><br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C0K:{(1S)-1-(3,4-DIFLUOROPHENYL)-4-[HYDROXY(METHYL)AMINO]-4-OXOBUTYL}PHOSPHONIC+ACID'>C0K</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k5h|1k5h]], [[1onp|1onp]], [[1q0l|1q0l]]</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1k5h|1k5h]], [[1onp|1onp]], [[1q0l|1q0l]]</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dxr, ispC, yaeM, b0173, JW0168 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dxr, ispC, yaeM, b0173, JW0168 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-deoxy-D-xylulose-5-phosphate_reductoisomerase 1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.267 1.1.1.267] </span></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r0i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r0i RCSB], [http://www.ebi.ac.uk/pdbsum/3r0i PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3r0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r0i OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3r0i RCSB], [http://www.ebi.ac.uk/pdbsum/3r0i PDBsum]</span></td></tr>
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<table>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/DXR_ECOLI DXR_ECOLI]] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).[HAMAP-Rule:MF_00183]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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Reverse Fosmidomycin Derivatives against the Antimalarial Drug Target IspC (Dxr).,Behrendt CT, Kunfermann A, Illarionova V, Matheeussen A, Pein MK, Grawert T, Kaiser J, Bacher A, Eisenreich W, Illarionov B, Fischer M, Maes L, Groll M, Kurz T J Med Chem. 2011 Aug 25. PMID:21866890<ref>PMID:21866890</ref>
Reverse Fosmidomycin Derivatives against the Antimalarial Drug Target IspC (Dxr).,Behrendt CT, Kunfermann A, Illarionova V, Matheeussen A, Pein MK, Grawert T, Kaiser J, Bacher A, Eisenreich W, Illarionov B, Fischer M, Maes L, Groll M, Kurz T J Med Chem. 2011 Aug 25. PMID:21866890<ref>PMID:21866890</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
== References ==
== References ==
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[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
[[Category: 1-deoxy-D-xylulose-5-phosphate reductoisomerase]]
[[Category: Ecoli]]
[[Category: Ecoli]]
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[[Category: Bacher, A.]]
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[[Category: Bacher, A]]
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[[Category: Behrendt, C T.]]
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[[Category: Behrendt, C T]]
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[[Category: Eisenreich, W.]]
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[[Category: Eisenreich, W]]
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[[Category: Fischer, M.]]
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[[Category: Fischer, M]]
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[[Category: Graewert, T.]]
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[[Category: Graewert, T]]
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[[Category: Groll, M.]]
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[[Category: Groll, M]]
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[[Category: Illarionov, B.]]
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[[Category: Illarionov, B]]
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[[Category: Illarionova, V.]]
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[[Category: Illarionova, V]]
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[[Category: Kunfermann, A.]]
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[[Category: Kunfermann, A]]
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[[Category: Kurz, T.]]
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[[Category: Kurz, T]]
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[[Category: Maes, L.]]
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[[Category: Maes, L]]
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[[Category: Matheeussen, A.]]
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[[Category: Matheeussen, A]]
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[[Category: Pein, M K.]]
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[[Category: Pein, M K]]
[[Category: Antimalarial agent]]
[[Category: Antimalarial agent]]
[[Category: Cytosol]]
[[Category: Cytosol]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]
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[[Category: ISPC]]
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[[Category: ISPC, Israel Structural Proteomics Center]]
[[Category: Mn]]
[[Category: Mn]]
[[Category: Nadph]]
[[Category: Nadph]]

Revision as of 14:06, 25 December 2014

IspC in complex with an N-methyl-substituted hydroxamic acid

3r0i, resolution 2.10Å

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OCA

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