4c7r

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{{STRUCTURE_4c7r| PDB=4c7r | SCENE= }}
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==Inward facing conformation of the trimeric betaine transporter BetP in complex with lipids==
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===Inward facing conformation of the trimeric betaine transporter BetP in complex with lipids===
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<StructureSection load='4c7r' size='340' side='right' caption='[[4c7r]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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{{ABSTRACT_PUBMED_24141878}}
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4c7r]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4C7R FirstGlance]. <br>
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==Function==
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CM5:5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE'>CM5</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGT:(1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+STEARATE'>PGT</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4c7r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4c7r OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4c7r RCSB], [http://www.ebi.ac.uk/pdbsum/4c7r PDBsum]</span></td></tr>
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</table>
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== Function ==
[[http://www.uniprot.org/uniprot/BETP_CORGL BETP_CORGL]] High-affinity uptake of glycine betaine (By similarity).
[[http://www.uniprot.org/uniprot/BETP_CORGL BETP_CORGL]] High-affinity uptake of glycine betaine (By similarity).
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bilayer lipids contribute to the stability of membrane transporters and are crucially involved in their proper functioning. However, the molecular knowledge of how surrounding lipids affect membrane transport is surprisingly limited and despite its general importance is rarely considered in the molecular description of a transport mechanism. One reason is that only few atomic resolution structures of channels or transporters reveal a functional interaction with lipids, which are difficult to detect in X-ray structures per se. Overcoming these difficulties, we report here on a new structure of the osmotic stress-regulated betaine transporter BetP in complex with anionic lipids. This lipid-associated BetP structure is important in the molecular understanding of osmoregulation due to the strong dependence of activity regulation in BetP on the presence of negatively charged lipids. We detected eight resolved palmitoyl-oleoyl phosphatidyl glycerol (PG) lipids mimicking parts of the membrane leaflets and interacting with key residues in transport and regulation. The lipid-protein interactions observed here in structural detail in BetP provide molecular insights into the role of lipids in osmoregulated secondary transport.
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==About this Structure==
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Structural evidence for functional lipid interactions in the betaine transporter BetP.,Koshy C, Schweikhard ES, Gartner RM, Perez C, Yildiz O, Ziegler C EMBO J. 2013 Oct 18. doi: 10.1038/emboj.2013.226. PMID:24141878<ref>PMID:24141878</ref>
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[[4c7r]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C7R OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<ref group="xtra">PMID:024141878</ref><references group="xtra"/><references/>
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</div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Micrococcus glutamicus kinoshita et al. 1958]]
[[Category: Micrococcus glutamicus kinoshita et al. 1958]]
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[[Category: Koshy, C.]]
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[[Category: Koshy, C]]
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[[Category: Yildiz, O.]]
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[[Category: Yildiz, O]]
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[[Category: Ziegler, C.]]
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[[Category: Ziegler, C]]
[[Category: Anionic lipid]]
[[Category: Anionic lipid]]
[[Category: Betaine transport]]
[[Category: Betaine transport]]

Revision as of 14:08, 25 December 2014

Inward facing conformation of the trimeric betaine transporter BetP in complex with lipids

4c7r, resolution 2.70Å

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